| Type | Description |
|---|---|
| Definition | 23S rRNA m(2)A2503 methyltransferase/tRNA m(2)A37 methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2016-04-30 11:30:00 | this study reports the x-ray structure of a key intermediate in the RlmN reaction, in which a Cys(118)-->Ala variant of the protein is cross-linked to a tRNA(Glu)substrate through the terminal methylene carbon of a formerly methylcysteinyl residue and C2 of adenosine 37. | 27081063 |
| 2012-12-08 10:02:00 | RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy. | 22891362 |
| 2012-04-07 12:13:00 | Reconstitution of the [4Fe-4S] cluster on wild-type apo RlmN followed by addition of S-adenosylmethionine results in rapid production of S-adenosylhomocysteine and the mCys residue. | 21916495 |
| 2011-06-18 10:35:00 | structure of RlmN and RlmN with SAM show single molecule of SAM coordinates [4Fe-4S] cluster; residue Cys(355) is S-methylated and located proximal to SAM methyl group, suggesting SAM that is involved in the initial methyl transfer binds at the same site | 21527678 |
| 2011-05-14 11:36:00 | SAM enzymes identified that methylate C atoms not inherently nucleophilic via intermediacy of 5'-deoxyadenosyl 5'-radical; determined reaction mechanism targeting sp(2)-hybridized carbons at position 2 and 8 of adenosine in 23S RRNA catalyzed by RlmN, Cfr | 21415317 |
| Type | IDs |
|---|---|
| Synonymous | ECK2513, yfgB |
| Gene |
UniProtKB-ID:
RLMN_ECOLI
UniprotKB:
P36979
UniParc:
UPI00000350B7
EMBL:
U02965,
U00096,
AP009048
EnsemblGenome:
b2517,
BAA16404
KO:
eco:b2517,
ecj:JW2501
|
| Nucleutide sequences |
EMBL-CDS:
AAC75570.1,
AAA21359.1,
BAA16404.1
EnsemblGenome_TRS:
AAC75570,
BAA16404
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA16404,
AAC75570
RefSeq:
NP_417012.1
|
| Others |
UniRef100:
UniRef100_A7ZPW0
UniRef90:
UniRef90_A7ZPW0
UniRef50:
UniRef50_Q0I3U8
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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