metC - cystathionine beta-lyase/L-cysteine desulfhydrase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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946240 metC

基因描述

Type	Description
Definition	cystathionine beta-lyase/L-cysteine desulfhydrase

研究结论

Date	Results	Publications
2017-05-20 14:17:00	a representative of fold type III, the Escherichia coli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL). Furthermore, E. coli CBL (fold type I) is a promiscuous alanine racemase. A single round of error-prone PCR and selection yielded variant ALR(Y274F), which catalyzes cystathionine beta-elimination with a near-native Michaelis constant (Km = 3.3 mm) but a poor turnover number (kcat approximate...	27474741
2012-01-07 11:34:00	A series of site-directed variants of CBL was constructed to investigate the roles of the hydroxyl moieties of active-site residues Y56, Y111, Y238, Y338, and S339 as determinants of specificity.	21958132
2007-11-05 21:38:00	N-terminus verified by Edman degradation on mature peptide	3513164,8663055

名称对应

Type	IDs
Synonymous	ECK3000
Gene	UniProtKB-ID: METC_ECOLI UniprotKB: P06721 UniParc: UPI0000110CEA EMBL: M12858, U28377, U00096, AP009048 EnsemblGenome: b3008, BAE77065 KO: ecj:JW2975, eco:b3008
Nucleutide sequences	EMBL-CDS: BAE77065.1, AAC76044.1, AAA69175.1, AAA24158.1 EnsemblGenome_TRS: AAC76044, BAE77065
Protein sequencees	EnsemblGenome_PRO: BAE77065, AAC76044 RefSeq: NP_417481.1
Others	UniRef100: UniRef100_P06721 UniRef90: UniRef90_P06721 UniRef50: UniRef50_P06721

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
29592871	Cystathionine Î²-lyase is involved in d-amino acid metabolism. Biochem. J. Tetsuya Miyamoto , Masumi Katane , Yasuaki Saitoh , Masae Sekine , Hiroshi Homma	2018-04-23	-
27474741	Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J Biol Chem Valerie W C Soo , Yuliana Yosaatmadja , Christopher J Squire , Wayne M Patrick	2016-09-16	-
21958132	Characterization of the side-chain hydroxyl moieties of residues Y56, Y111, Y238, Y338, and S339 as determinants of specificity in E. coli cystathionine Î²-lyase. Biochemistry Pratik H Lodha , Susan M Aitken	2011-11-15	metC
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
19370061	Interconversion of a pair of active-site residues in Escherichia coli cystathionine gamma-synthase, E. coli cystathionine beta-lyase, and Saccharomyces cerevisiae cystathionine gamma-lyase and development of tools for the investigation of their mechanisms and reaction specificity. Biochem. Cell Biol. Ali Farsi , Pratik H Lodha , Jennifer E Skanes , Heidi Los , Navya Kalidindi , Susan M Aitken	2009-04-01	metC, atpF, metB
17187058	Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol. Peng Lu , Christine Vogel , Rong Wang , Xin Yao , Edward M Marcotte	2007-01-01	sspA, talB, dnaK, dnaJ, rpsT, ileS, dapB, carB, ftsZ, murE, aceF, acpP, surA, secA, can, aceE, panB, argF, lpxA, dksA, lpd, erpA, skp, dapD, acnB, tsf, glnH, fabZ, metQ, accA, galM, sodB, panC, pyrH, codA, opgG, pepD, tauB, eno, proC, phoR, thiI, gpmA, leuC, tig, clpP, clpX, lon, adk, htpG, acrB, trpD, apt, ydgH, rplT, purK, ompT, thrC, ybeD, ahpC, purR, glf, serA, miaB, pgm, seqA, rfbB, iscR, asnB, mprA, fldA, fur, sucA, sucB, hisJ, glnS, sucC, sucD, gltA, bioB, pheT, bioD, metK, sdhA, ybiC, tolB, ybiT, ldtB, moeA, gsiB, yliE, ihfA, serS, pflB, serC, aroA, ihfB, rpsA, mukE
17012394	Experimental and computational assessment of conditionally essential genes in Escherichia coli. J. Bacteriol. Andrew R Joyce , Jennifer L Reed , Aprilfawn White , Robert Edwards , Andrei Osterman , Tomoya Baba , Hirotada Mori , Scott A Lesely , Bernhard Ã Palsson , Sanjay Agarwalla	2006-12-01	carB, leuB, cra, panB, pdxA, panC, proC, leuC, trpD, purK, fes, thrC, serA, gltA, nadA, trpC, serC, aroA, pyrD, leuD, panD, icd, trpB, cysB, pyrC, thrA, trpE, leuL, trpA, aroD, metC, pabB, proB, hisI, hisF, hisA, hisD, hisH, hisG, hisC, hisB, ubiG, proA, pdxB, purF, pdxH, aroC, cysK, ptsI, crr, cysU, cysP, cysA, purC, purM, guaB, iscS, glyA, purL, pdxJ, nadB, pheA, tyrA, pyrF, cysD, cysN, cysC, cysH, cysI, cysJ, argA, lysA, guaA, prfB, ubiH, leuA, thrB, folB, rpsU, folP, glmM, aroE, pabA, aroB, glpD, panM, cysE, pyrE, ilvB, atpA, atpG, atpC, atpF, atpB, atpH, ilvD, ilvC, ilvA, metR
16820464	Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Appl. Environ. Microbiol. Martin KÃ¶stner , Britta Schmidt , Ralph Bertram , Wolfgang Hillen	2006-07-01	yhdP, nirC, carB, leuB, mraZ, panB, argP, panC, cvpA, leuC, entF, serA, gltA, bioB, bioA, sfmH, trpC, serC, pyrD, hflD, trpB, cysB, thrA, trpE, ydeO, rclA, lhr, entB, trpA, metC, hisB, fruK, proA, menD, pdxB, truA, cysP, purC, bamB, tyrA, pyrF, cysD, cysJ, glcA, leuA, argG, prmA, lptC, rplM, argD, cysG, aroB, cspA, mtlA, waaG, yidL, ilvD, ilvY, ilvC, ilvA, metE, metB, argC, argE, ppc, thiC, purH, metA, xylE, pgi, cysQ, yjhF
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM

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