Type | Description |
---|---|
Definition | tail-specific protease |
Date | Results | Publications |
---|---|---|
2020-06-06 13:32:00 | We demonstrated for the first time that Prc is essential for full Extraintestinal pathogenic E. coli (ExPEC) virulence in urinary tract infections. Our results collectively support the idea that Prc is essential for bacterial envelope integrity, thus explaining how Prc deficiency results in an attenuated ExPEC. | 31900139 |
2020-05-02 10:51:00 | In Prc, a hydrophobic substrate sensor engages substrate binding to the PDZ domain and triggers a structural remodeling to align the active-site residues. | 31387902 |
2018-10-06 10:30:00 | A proteolytic system comprising the periplasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contributes to Peptidoglycan (PG) enlargement. | 29138488 |
2014-04-19 10:05:00 | ProQ and Prc deficiencies lowered the ProP activity of bacteria cultivated at moderate salinity by approximately 70% and 30%, respectively, but did not affect other osmoregulatory functions. | 24443528 |
2007-11-05 21:38:00 | N-terminus verified by Edman degradation on mature peptide | 1729701 |
Type | IDs |
---|---|
Synonymous | ECK1829, tsp |
Gene |
UniProtKB-ID:
PRC_ECOLI
UniprotKB:
P23865
UniParc:
UPI0000132178
EMBL:
D00674,
AP009048,
S49803,
U00096,
L48409,
M75634
EnsemblGenome:
b1830,
BAA15638
KO:
ecj:JW1819,
eco:b1830
|
Nucleutide sequences |
EMBL-CDS:
BAA00578.1,
AAD41528.1,
AAB24313.1,
AAA24699.1,
BAA15638.1,
AAC74900.1,
BAA00577.1
EnsemblGenome_TRS:
BAA15638,
AAC74900
|
Protein sequencees |
EnsemblGenome_PRO:
BAA15638,
AAC74900
RefSeq:
NP_416344.1
|
Others |
UniRef100:
UniRef100_P23865
UniRef90:
UniRef90_P23865
UniRef50:
UniRef50_P23865
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
暂无数据
Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
---|---|---|---|
31900139 |
J. Biomed. Sci. Wen-Chun Huang , Chung-Yen Lin , Masayuki Hashimoto , Jiunn-Jong Wu , Ming-Cheng Wang , Wei-Hung Lin , Chang-Shi Chen , Ching-Hao Teng |
2020-01-03 | - |
31387902 |
mBio Chuang-Kai Chueh , Nilanjan Som , Lu-Chu Ke , Meng-Ru Ho , Manjula Reddy , Chung-I Chang |
2019-08-06 | - |
29138488 |
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nat Commun Ming-Yuan Su , Nilanjan Som , Chia-Yun Wu , Shih-Chieh Su , Yi-Ting Kuo , Lu-Chu Ke , Meng-Ru Ho , Shiou-Ru Tzeng , Ching-Hao Teng , Dominique Mengin-Lecreulx , Manjula Reddy , Chung-I Chang |
2017-11-15 | - |
24443528 |
Salinity-dependent impacts of ProQ, Prc, and Spr deficiencies on Escherichia coli cell structure. J. Bacteriol. Craig H Kerr , Doreen E Culham , David Marom , Janet M Wood |
2014-03-01 |
prc,
mepS,
proQ
|
25426869 |
Degradation of C-terminal tag sequences on domain antibodies purified from E. coli supernatant. MAbs Simon Lykkemark , Ole Aalund Mandrup , Niels Anton Friis , Peter Kristensen |
2014-01-01 | - |
21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
16381862 |
MEROPS: the peptidase database. Nucleic Acids Res. Neil D Rawlings , Fraser R Morton , Alan J Barrett |
2006-01-01 |
yghX,
lspA,
rseP,
yafL,
yafJ,
mhpC,
hypF,
yahJ,
frmB,
codA,
pepD,
yfhR,
yajL,
clpP,
lon,
trpD,
allB,
allC,
loiP,
ompT,
mepH,
dacA,
asnB,
ybfF,
nagA,
dacC,
iaaA,
ddpX,
ycaL,
ycbK,
ycbZ,
hyaD,
cohE,
abgA,
umuD,
ldcA,
pyrC,
yfbL,
sohB,
puuD,
abgB,
mpaA,
ynbC,
ycjY,
ydcP,
pqqL,
htpX,
dcp,
prc,
pyrG,
nlpC,
sppA,
tsaB,
pepT,
ptrB,
mepM,
ydgD,
hchA,
dacD,
rutD,
yegQ,
pbpG,
mepS,
menH,
elaD,
purF,
mepA,
ypdE,
ypdF,
ampH,
yfeW,
nlpD,
bepA,
lepB,
degP,
iap,
pepN,
ptrA,
guaA,
ygeR,
hyuA,
ygeY,
guaD,
pepP,
hycI,
pppA,
aes,
tsaD,
agaA,
yhbO,
ftsH,
dacB,
gltB,
tldD,
degQ,
gspO,
yheT,
degS,
pabA
|
16397293 |
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner |
2006-01-01 |
pmrR,
yfaS,
torI,
yaeP,
ykfH,
ykgO,
ylcG,
rzoD,
ybdZ,
cydX,
gnsA,
insA,
ymgF,
ymiA,
yciX,
rzoR,
ynfO,
yniD,
yobH,
yoeF,
yoeB,
yohO,
arnE,
ypdJ,
ypeB,
ypfN,
ypjJ,
arfA,
yheV,
ysaB,
sgcB,
yjhX,
ytjA,
yibT,
yicS,
yidD,
yifL,
ghoT,
yjjZ,
mntS,
iroK,
yifN,
wecF,
yigE,
blr,
yggP,
cpxP,
ygaY,
hdfR,
thiS,
yedN,
greB,
rtcA,
smf,
ygcU,
ypjK,
hokE,
sslE,
glcF,
glcE,
glvC,
yhaM,
tdcG,
ytfR,
yehH,
hokB,
ldrD,
hokA,
ldrA,
ldrB,
ecnA,
ecnB,
gapC,
yfjD,
yhdP,
yjjV,
cysW,
hokC,
ghxQ,
tatD,
yjdP,
cutC,
nirC,
frlC,
aroK,
gntU,
yedS,
dgoD,
dgoA,
dgoR,
yigL,
ldrC,
ylbE,
ydbJ,
yeiW,
yehK,
yaiX,
yoeA,
yneM
|
16738553 |
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi |
2006-01-01 |
pmrR,
torI,
yaeP,
ykfH,
ykgO,
ylcG,
rzoD,
ybdZ,
cydX,
gnsA,
insA,
ymgF,
ymiA,
yciX,
rzoR,
ynfO,
yniD,
yobH,
yoeB,
yohO,
arnE,
ypeB,
ypfN,
ypjJ,
arfA,
yheV,
ysaB,
sgcB,
yjhX,
ytjA,
yibT,
yicS,
yidD,
yifL,
ghoT,
yjjZ,
mntS,
iroK,
wecF,
yigE,
blr,
yggP,
cpxP,
hdfR,
thiS,
greB,
rtcA,
smf,
ygcU,
ypjK,
hokE,
sslE,
glcF,
glcE,
yhaM,
tdcG,
ytfR,
hokB,
ldrD,
hokA,
ldrA,
ldrB,
ecnA,
ecnB,
yfjD,
yhdP,
yjjV,
cysW,
hokC,
ghxQ,
tatD,
yjdP,
cutC,
nirC,
frlC,
aroK,
gntU,
dgoD,
dgoA,
dgoR,
yigL,
ldrC,
ylbE,
ydbJ,
yeiW,
yehK,
yneM,
ykfM,
ylcI,
yciY,
yncL,
ylcH,
ynhF,
yciZ,
ydgU,
ypfM,
ymgI,
ymgJ,
dinQ
|
15004283 |
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. Jaya K Kumar , Stanley Tabor , Charles C Richardson |
2004-03-16 |
talB,
ftsZ,
dksA,
dapD,
acnB,
tsf,
fabZ,
pyrH,
lacZ,
eno,
yajQ,
clpP,
htpG,
ybeD,
ahpC,
fur,
sucC,
sucD,
sdhA,
ompF,
fabA,
ompA,
putA,
ndk,
fabG,
icd,
yqaB,
tdk,
add,
fabI,
tpx,
ydjA,
prc,
yebE,
pykA,
flu,
nrdA,
mqo,
ompC,
crr,
ffh,
recA,
sdaB,
fbaA,
nrdR,
rcsB,
gapA,
glmM,
obgE,
lptB,
fusA,
slyD,
ompR,
cspA,
rpoZ,
tnaA,
atpA,
atpD,
glmU,
rbsB,
trxA,
fadB,
fdoG,
sodA,
tpiA,
hslU,
katG,
sthA,
nusG,
malE,
lamB,
mreB,
groS,
efp,
fklB,
nrdD,
yjiA,
ubiE,
udp,
mglA,
hupB
|
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