| Type | Description |
|---|---|
| Definition | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-02 11:55:00 | In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15]. | 28333213 |
| 2017-08-05 11:10:00 | we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease | 27182061 |
| 2016-05-14 11:26:00 | show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex | 26507661 |
| 2016-04-30 11:30:00 | The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. | 26177020 |
| 2015-02-14 11:20:00 | c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior | 25450678 |
| Type | IDs |
|---|---|
| Synonymous | COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX |
| Gene |
UniProtKB-ID:
ARHG6_HUMAN,
B7Z3C7_HUMAN,
Q8N4Q3_HUMAN
UniprotKB:
Q15052,
B7Z3C7,
Q8N4Q3
UniParc:
UPI0001914B9A,
UPI000006E528,
UPI0000001C8E,
UPI00004A3A32
EMBL:
D13631,
AK295709,
BC033768,
AF207831,
AL683813,
BX537390,
BC039856,
AK291742,
BC043505,
CH471150,
AL135783,
AK294929,
D25304
Ensembl:
ENSG00000129675
KO:
hsa:9459
|
| Nucleutide sequences |
EMBL-CDS:
BAA02796.1,
BAH11929.1,
EAW88461.1,
AAG27169.1,
CAD97632.1,
BAA04985.1,
AAH39856.1,
AAH43505.1,
EAW88460.1,
BAF84431.1,
BAH12163.1,
AAH33768.1
Ensembl_TRS:
ENST00000370620,
ENST00000250617,
ENST00000370622
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000250617,
ENSP00000359656,
ENSP00000359654
RefSeq:
XP_011529714.1,
XP_011529716.1,
NP_001293106.1,
XP_011529717.1,
XP_011529715.1,
XP_005262556.1,
XP_016885464.1,
XP_011529718.1,
NP_004831.1
|
| Others |
UniRef100:
UniRef100_Q8N4Q3,
UniRef100_Q15052,
UniRef100_B7Z3C7
UniRef90:
UniRef90_Q8N4Q3,
UniRef90_Q15052,
UniRef90_A0A2K5L781
UniRef50:
UniRef50_Q15052,
UniRef50_A0A3L7H2L5
UniGene:
Hs.522795
CCDS:
CCDS78509.1,
CCDS14660.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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