| Type | Description |
|---|---|
| Definition | DNA topoisomerase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:52:00 | Supercoiling, R-loops, Replication and the Functions of Bacterial Type 1A Topoisomerases. | 32120891 |
| 2020-03-21 10:35:00 | we observe that a single residue substitution (R168C) results in a high rate of head-to-tail (tandem) short sequence duplications, which are independent of existing sequence repeats. Finally, we show that the unique mutation spectrum of topA mutants enhances the emergence of antibiotic resistance in comparison to mismatch-repair (mutS) mutators, and leads to new resistance genotypes. | 31777935 |
| 2019-01-19 11:12:00 | Study finding that both E. coli topo I and III control R-loop formation/accumulation, mostly to inhibit unregulated replication, may suggest that R-loops have been a problem early in the evolution of life. Furthermore, data show that E. coli cells can survive in the absence of type 1A topos, owing to the surproduction of topo IV that can relax excess negative supercoiling and prevent R-loop formation. | 30222737 |
| 2018-07-21 11:27:00 | the CyaA(N600Y) mutant has a transcriptome indicative of increased CRP activity, pointing to an unknown role for CyaA and / or cAMP in gene expression..We show that the large scale transcriptomic changes in the topoisomerase I (FusA(A608E)-TopA(S180L)) mutant likely result from increased negative supercoiling in the cell. | 29046437 |
| 2016-09-10 10:18:00 | Escherichia coli RecA physically interacts with topoisomerase I to modulate the chromosomal DNA supercoiling. | 27001450 |
| Type | IDs |
|---|---|
| Synonymous | ECK1268, supX |
| Gene |
UniProtKB-ID:
TOP1_ECOLI
UniprotKB:
P06612
UniParc:
UPI0000137136
EMBL:
AP009048,
M15041,
X04475,
U00096
EnsemblGenome:
b1274,
BAA14811
KO:
eco:b1274,
ecj:JW1266
|
| Nucleutide sequences |
EMBL-CDS:
AAA23641.1,
BAA14811.1,
CAA28164.1,
AAC74356.1
EnsemblGenome_TRS:
AAC74356,
BAA14811
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA14811,
AAC74356
RefSeq:
NP_415790.1
|
| Others |
UniRef100:
UniRef100_P06612
UniRef90:
UniRef90_P06612
UniRef50:
UniRef50_P06612
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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