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945787 pyrC

945787

pyrC

dihydroorotase

protein-coding

Escherichia coli str. K-12 substr. MG1655

基因描述

Type Description
Definition dihydroorotase

研究结论

Date Results Publications
2010-01-21 00:00:00 The kinetic and structural analyses suggest that Thr109 and Thr110 in the flexible loop provide productive binding of substrate and stabilize the transition-state intermediate, thereby increasing catalytic activity. 17711307
2010-01-21 00:00:00 Results show that a loop comprised of residues 105-115 of dihydroorotase has different conformations in its two subunits. 15826651
2010-01-21 00:00:00 we report the structures of Escherichia coli DHOase crystallized without ligand (1.7 A resolution) and in the presence of the inhibitors 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylate (2.0 A) and 5-fluoroorotate (2.2 A). 17550785
2010-01-21 00:00:00 DAta show that expression of chromosomal dihydroorotase activity and beta-galactosidase activity of pyrC-lacZ fusion plasmid was repressed to about 30% and 17%, respectively in the fur+ strain compared to those in the fur- strain. 18176545
2007-11-05 21:38:00 N-terminus verified by Edman degradation on mature peptide 9298646

名称对应

Type IDs
Synonymous ECK1047
Gene
UniProtKB-ID: PYRC_ECOLI
UniprotKB: P05020
UniParc: UPI0000168075
EMBL: D31709, U00096, M16752, X04469, AP009048
EnsemblGenome: b1062, BAA35870
KO: eco:b1062, ecj:JW1049
Nucleutide sequences
EMBL-CDS: BAA35870.1, AAC74146.1, AAA24482.1, CAA28157.1, BAA06514.1
EnsemblGenome_TRS: BAA35870, AAC74146
Protein sequencees
EnsemblGenome_PRO: AAC74146, BAA35870
RefSeq: NP_415580.1
Others
UniRef100: UniRef100_C4ZS02
UniRef90: UniRef90_Q8X8N8
UniRef50: UniRef50_P06204

全选

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