mcrA - e14 prophage; 5-methylcytosine-specific restriction enzyme McrA-BMKCloudï½ç¾è¿å®¢äº

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945727 mcrA

基因描述

Type	Description
Definition	e14 prophage; 5-methylcytosine-specific restriction enzyme McrA

研究结论

Date	Results	Publications
2019-06-29 11:55:00	EcoKMcrA DNA endonuclease activity requires Mn2+ ions, is not strictly methyl dependent, and is not observed when active site variants of the enzyme are used. In cells, EcoKMcrA specifically restricts DNA that is modified in the correct sequence context. This activity is impaired by mutations of the nuclease active site, unless the enzyme is highly overexpressed.	30107581
2010-01-21 00:00:00	Cloning, purification and initial characterization of E. coli McrA, a putative 5-methylcytosine-specific nuclease	18662788

名称对应

Type	IDs
Synonymous	ECK1145, rglA
Gene	UniProtKB-ID: MCRA_ECOLI UniprotKB: P24200 UniParc: UPI000012EDB2 EMBL: M76667, U00096, AP009048, Z19104 EnsemblGenome: BAA35995, b1159 KO: eco:b1159, ecj:JW1145
Nucleutide sequences	EMBL-CDS: CAA79520.1, BAA35995.1, AAC74243.1, AAA68481.1 EnsemblGenome_TRS: AAC74243, BAA35995
Protein sequencees	EnsemblGenome_PRO: AAC74243, BAA35995 RefSeq: NP_415677.1
Others	UniRef100: UniRef100_P24200 UniRef90: UniRef90_P24200 UniRef50: UniRef50_P24200

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
30107581	Activity and structure of EcoKMcrA. Nucleic Acids Res. Honorata Czapinska , Monika Kowalska , Evelina Zagorskaite , Elena Manakova , Anton Slyvka , Shuang-Yong Xu , Virginijus Siksnys , Giedrius Sasnauskas , Matthias Bochtler	2018-10-12	-
20015968	Differential binding of Escherichia coli McrA protein to DNA sequences that contain the dinucleotide m5CpG. Nucleic Acids Res Elizabeth A Mulligan , Eli Hatchwell , Sean R McCorkle , John J Dunn	2010-04-01	-
18662788	Cloning, purification and initial characterization of E. coli McrA, a putative 5-methylcytosine-specific nuclease. Protein Expr. Purif. Elizabeth A Mulligan , John J Dunn	2008-11-01	mcrA
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
15317774	Transposon-mediated linker insertion scanning mutagenesis of the Escherichia coli McrA endonuclease. J. Bacteriol. Brian P Anton , Elisabeth A Raleigh	2004-09-01	mcrA
14733619	Analysis of the lambdoid prophage element e14 in the E. coli K-12 genome. BMC Microbiol. Preeti Mehta , Sherwood Casjens , Sankaran Krishnaswamy	2004-01-20	oweE, aaaE, stfR, ymfD, beeE, ymfR, icd, jayE, xisE, ymfQ, ymfI, ymfM, ymfL, ymfJ, cohE, croE, pinE, stfE, tfaE, tfaP, stfP, mcrA, ymfE, intE, lit
12886937	Prophages and bacterial genomics: what have we learned so far? Mol. Microbiol. Sherwood Casjens	2003-07-01	-
10972843	Atomic model of the 5-methylcytosine-specific restriction enzyme McrA reveals an atypical zinc finger and structural similarity to betabetaalphaMe endonucleases. Mol. Microbiol. J M Bujnicki , M Radlinska , L Rychlewski	2000-09-01	-
9278503	The complete genome sequence of Escherichia coli K-12. Science F R Blattner , G Plunkett , C A Bloch , N T Perna , V Burland , M Riley , J Collado-Vides , J D Glasner , C K Rode , G F Mayhew , J Gregor , N W Davis , H A Kirkpatrick , M A Goeden , D J Rose , B Mau , Y Shao	1997-09-05	-

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