| Type | Description |
|---|---|
| Definition | chromosome partitioning protein MukB |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:07:00 | Organization of the Escherichia coli Chromosome by a MukBEF Axial Core. | 32097603 |
| 2019-12-07 12:09:00 | Complex formation requires functional interactions between the C- and N-terminal domains of MukF with the MukB head and neck, respectively, and MukE, which organizes the complexes by stabilizing binding of MukB heads to MukF. In the absence of head engagement, a MukF dimer bound by MukE forms complexes containing only a dimer of MukB. | 31400115 |
| 2019-08-17 12:12:00 | The authors show that a 4-helix bundle adjacent to the MukF dimerisation domain interacts functionally with the MukB coiled-coiled 'neck' adjacent to the ATPase head. They propose that this interaction leads to an asymmetric tripartite complex, as in other SMC (Structural Maintenance of Chromosomes) complexes. | 29323635 |
| 2018-07-14 12:14:00 | Study reports that MukB binds topologically to DNA in vitro, and this binding is preferentially single-stranded DNA (ssDNA) rather than double-stranded DNA. The binding of MukB to ssDNA does not require ATP but the thermal energy enhances the binding. | 27387439 |
| 2017-10-21 12:53:00 | Cells carrying a mukB mutant allele that encodes a protein that does not interact with topoisomerase IV exhibit severe nucleoid decompaction leading to chromosome segregation defects. These findings suggest that the MukB-topoisomerase IV complex may provide a scaffold for DNA condensation. | 28842485 |
| Type | IDs |
|---|---|
| Synonymous | ECK0915 |
| Gene |
UniProtKB-ID:
MUKB_ECOLI
UniprotKB:
P22523
UniParc:
UPI000012F8EE
EMBL:
AP009048,
U00096,
X57550,
D26440,
D31701
EnsemblGenome:
BAA35670,
b0924
KO:
ecj:JW0907,
eco:b0924
|
| Nucleutide sequences |
EMBL-CDS:
CAA40776.1,
BAA35670.1,
BAA05459.1,
AAC74010.1,
BAA06510.1
EnsemblGenome_TRS:
BAA35670,
AAC74010
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA35670,
AAC74010
RefSeq:
NP_415444.1
|
| Others |
UniRef100:
UniRef100_C4ZQ50
UniRef90:
UniRef90_A8AIF5
UniRef50:
UniRef50_P45187
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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