| Type | Description |
|---|---|
| Definition | multidrug efflux pump MdfA/Na(+):H(+) antiporter/K(+):H(+) antiporter |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:15:00 | Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels. | 31467343 |
| 2020-05-02 10:21:00 | analysis of MdfA variant I239T/G354E in complexes with three electrically different ligands reveals the molecular basis for substrate recognition | 31240248 |
| 2019-01-12 11:00:00 | Outward open conformation of the Major Facilitator Superfamily multidrug/H(+) antiporter MdfA from Escherichia coli has changes in relative orientations of the N- and C-terminal lobes, and transmembrane helix5 (TM5) is kinked and twisted. In vitro reconstitution experiments demonstrate the importance of selected residues for transport and molecular dynamics simulations provide insights into antiporter switching. | 30275448 |
| 2018-11-10 10:16:00 | MdfA has exceptional promiscuous capabilities not only in its interaction with a plethora of chemically dissimilar compounds, but also concerning the various faces of its modes of energy consumption. [review] | 28951231 |
| 2017-12-09 13:13:00 | Crystallization and X-ray diffraction analysis of the multidrug-resistance transporter MdfA from Escherichia coli has been reported. | 28695852 |
| Type | IDs |
|---|---|
| Synonymous | ECK0832, cmlA, cmr |
| Gene |
UniProtKB-ID:
MDFA_ECOLI
UniprotKB:
P0AEY8
UniParc:
UPI000012EE0B
EMBL:
Y08743,
U44900,
AP009048,
U00096
EnsemblGenome:
b0842,
BAA35546
KO:
eco:b0842,
ag:CAA69997,
ecj:JW0826
|
| Nucleutide sequences |
EMBL-CDS:
AAC73929.1,
BAA35546.1,
AAC44147.1,
CAA69997.1
EnsemblGenome_TRS:
BAA35546,
AAC73929
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73929,
BAA35546
RefSeq:
NP_415363.1
|
| Others |
UniRef100:
UniRef100_P0AEZ0
UniRef90:
UniRef90_Q323U7
UniRef50:
UniRef50_Q323U7
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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