| Type | Description |
|---|---|
| Definition | D-alanyl-D-alanine carboxypeptidase DacA |
| Date | Results | Publications |
|---|---|---|
| 2019-06-15 11:02:00 | Study reports the structure of a E.coli PBP5-meropenem acyl enzyme complex in order to completely describe the molecular interactions which facilitate meropenem inhibition of the YcbB and PBP5 partners. Results provide structural insight into D,D-transpeptidase bypass in E. coli and structural insight into the role of L,D-transpeptidation of PG in Gram negative bacteria. | 31015395 |
| 2018-09-22 11:36:00 | Studied alanine substitution with glutamic acid at Position 184 in Escherichia coli D-alanyl-D-alanine carboxypeptidase (PBP5); results found substitution of A184 to E of Omega-like loop alone can introduce cephalosporinase activity in E. coli PBP5. | 29549627 |
| 2013-04-20 13:16:00 | Authors infer that biochemically DacD and PBP5 are more closely related to each other than to PBP6, enabling DacD and PBP5 to play a nearly similar physiological function in terms of recovering the lost beta-lactam resistance. | 22978571 |
| 2011-07-23 10:25:00 | The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6 and thereby demonstrating the versatility of BolA as a cellular regulator. | 21464593 |
| 2011-05-21 10:33:00 | Results indicating a change in the active-site microarchitectures of PBP5 and 6 as a plausible cause of the difference in their biochemical behaviors. | 21163680 |
| Type | IDs |
|---|---|
| Synonymous | ECK0625, pfv |
| Gene |
UniProtKB-ID:
DACA_ECOLI
UniprotKB:
P0AEB2
UniParc:
UPI0000128DD7
EMBL:
X06479,
L07636,
M18276,
U00096,
U82598,
AP009048
EnsemblGenome:
BAA35275,
b0632
KO:
ecj:JW0627,
eco:b0632
|
| Nucleutide sequences |
EMBL-CDS:
AAA66340.1,
AAA24553.1,
AAB40832.1,
CAA29774.1,
BAA35275.1,
AAC73733.1
EnsemblGenome_TRS:
BAA35275,
AAC73733
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73733,
BAA35275
RefSeq:
NP_415165.1
|
| Others |
UniRef100:
UniRef100_P0AEB4
UniRef90:
UniRef90_P0AEB4
UniRef50:
UniRef50_P0AEB4
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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