| Type | Description |
|---|---|
| Definition | ABC-type tripartite efflux pump ATP binding/membrane subunit |
| Date | Results | Publications |
|---|---|---|
| 2018-06-02 10:04:00 | A hexamer of the periplasmic protein MacA bridges between a TolC trimer in the outer membrane and a MacB dimer in the inner membrane, generating a quaternary structure with a central channel for substrate translocation. | 28504659 |
| 2017-11-25 14:14:00 | Structural comparison with the previously reported MacB periplasmic domain structure suggests a molecular mechanism for regulation of the activity of MacB via an interaction between the MacB periplasmic domain and MacA. Our results provide a better understanding of the tripartite pumps at the molecular level. | 29061301 |
| 2015-07-25 10:34:00 | Protoporphyrin (PPIX) efflux is mediated by the MacAB-TolC pump .Protoporphyrin (PPIX) efflux by the MacAB-TolC pump. | 25257218 |
| 2011-12-03 10:27:00 | We propose that MacA acts in transport by promoting MacB transition into the closed ATP-bound conformation and in this respect, is similar to the periplasmic solute-binding proteins. | 21696464 |
| 2010-01-21 00:00:00 | MacA stimulated MacB ATPase only in phospholipid bilayers and did not need the presence of macrolides, these results suggest that MacA is a functional subunit of the MacB transporter. | 17214741 |
| Type | IDs |
|---|---|
| Synonymous | ECK0870, ybjZ |
| Gene |
UniProtKB-ID:
MACB_ECOLI
UniprotKB:
P75831
UniParc:
UPI000012EB0B
EMBL:
U00096,
AP009048,
AB071146
EnsemblGenome:
BAA35598,
b0879
KO:
eco:b0879,
ecj:JW0863
|
| Nucleutide sequences |
EMBL-CDS:
BAB64542.1,
BAA35598.1,
AAC73966.1
EnsemblGenome_TRS:
BAA35598,
AAC73966
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA35598,
AAC73966
RefSeq:
NP_415400.1
|
| Others |
UniRef100:
UniRef100_P75831
UniRef90:
UniRef90_P75831
UniRef50:
UniRef50_P75831
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员