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945164 macB

945164

macB

ABC-type tripartite efflux pump ATP binding/membrane subunit

protein-coding

Escherichia coli str. K-12 substr. MG1655

基因描述

Type Description
Definition ABC-type tripartite efflux pump ATP binding/membrane subunit

研究结论

Date Results Publications
2018-06-02 10:04:00 A hexamer of the periplasmic protein MacA bridges between a TolC trimer in the outer membrane and a MacB dimer in the inner membrane, generating a quaternary structure with a central channel for substrate translocation. 28504659
2017-11-25 14:14:00 Structural comparison with the previously reported MacB periplasmic domain structure suggests a molecular mechanism for regulation of the activity of MacB via an interaction between the MacB periplasmic domain and MacA. Our results provide a better understanding of the tripartite pumps at the molecular level. 29061301
2015-07-25 10:34:00 Protoporphyrin (PPIX) efflux is mediated by the MacAB-TolC pump .Protoporphyrin (PPIX) efflux by the MacAB-TolC pump. 25257218
2011-12-03 10:27:00 We propose that MacA acts in transport by promoting MacB transition into the closed ATP-bound conformation and in this respect, is similar to the periplasmic solute-binding proteins. 21696464
2010-01-21 00:00:00 MacA stimulated MacB ATPase only in phospholipid bilayers and did not need the presence of macrolides, these results suggest that MacA is a functional subunit of the MacB transporter. 17214741

名称对应

Type IDs
Synonymous ECK0870, ybjZ
Gene
UniProtKB-ID: MACB_ECOLI
UniprotKB: P75831
UniParc: UPI000012EB0B
EMBL: U00096, AP009048, AB071146
EnsemblGenome: BAA35598, b0879
KO: eco:b0879, ecj:JW0863
Nucleutide sequences
EMBL-CDS: BAB64542.1, BAA35598.1, AAC73966.1
EnsemblGenome_TRS: BAA35598, AAC73966
Protein sequencees
EnsemblGenome_PRO: BAA35598, AAC73966
RefSeq: NP_415400.1
Others
UniRef100: UniRef100_P75831
UniRef90: UniRef90_P75831
UniRef50: UniRef50_P75831

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