| Type | Description |
|---|---|
| Definition | protein/nucleic acid deglycase 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 12:01:00 | The Parkinsonism-associated protein DJ-1 and its bacterial homologs deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL function as deglycases that repair proteins and nucleotides from endogeneous glycation by glyoxal and methylglyoxal. DJ-1, deglycase 1 and deglycase 2 repair glyoxal- and methylglyoxal-glycated substrates, whereas deglycase 3 principally repairs glyoxal-glycated substrates. | 29932913 |
| 2016-10-22 10:42:00 | Purified YajL, YhbO and ElbB exhibited glyoxalase activity with different substrate specificities, optimal pHs and metal effects. | 26678554 |
| 2016-06-28 10:27:00 | Moreover, yhbO and yajL mutants display decreased viability in methylglyoxal- or glucose-containing media | 26774339 |
| 2013-04-20 14:03:00 | protein defects resulting from the yajL mutation trigger the onset of a robust and global stress response in a prokaryotic model of DJ-1-associated Parkinsonism. | 23292772 |
| 2012-10-06 10:21:00 | YajL and possibly DJ-1 function as covalent chaperones involved in the detection of sulfenylated proteins by forming mixed disulfides with them and that these disulfides are subsequently reduced by low-molecular-weight thiols. | 22321799 |
| Type | IDs |
|---|---|
| Synonymous | ECK0418, thiJ |
| Gene |
UniProtKB-ID:
YAJL_ECOLI
UniprotKB:
Q46948
UniParc:
UPI0000136E2F
EMBL:
U82664,
AP009048,
U34923,
U00096
EnsemblGenome:
b0424,
BAE76204
KO:
eco:b0424,
ecj:JW5057
|
| Nucleutide sequences |
EMBL-CDS:
AAC73527.2,
AAB40180.1,
AAA82704.1,
BAE76204.1
EnsemblGenome_TRS:
BAE76204,
AAC73527
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE76204,
AAC73527
RefSeq:
NP_414958.4
|
| Others |
UniRef100:
UniRef100_Q46948
UniRef90:
UniRef90_Q46948
UniRef50:
UniRef50_Q46948
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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