dinB - DNA polymerase IV-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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944922 dinB

基因描述

Type	Description
Definition	DNA polymerase IV

研究结论

Date	Results	Publications
2020-10-24 14:10:00	Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair.	32687193
2019-12-14 11:31:00	the amino acid patch of highly conserved residues in DinB-like proteins provides a mechanistic explanation for DinB's function in strand exchange and improves our understanding of recombination by providing evidence that RecA plays a role in facilitating DinB's activity during strand exchange.	30872406
2018-06-23 11:08:00	In an SOS-constitutive mutant that expresses high levels of pol IV, few foci are observed in the absence of damage, indicating that within cells access of pol IV to DNA is dependent on the presence of damage, as opposed to concentration-driven competition for binding sites.	29351274
2017-08-26 12:49:00	We hypothesize that damaged bases allow the switch to use of Pol IV during MBR by pausing the replicative polymerase to allow polymerase exchange in the replisome. The findings suggest that spontaneous mutation by MBR is regulated by regulation of the intracellular level of	28727736
2017-08-05 10:11:00	A mathematical model let us define the geometry (infer the structure) of the toxic intermediate as being formed when NER incises a lesion that resides in close proximity of another lesion in the complementary strand. This critical NER intermediate requires Pol IV / Pol II for repair, it is either lethal if left unrepaired or mutation-prone when repaired	28686598

名称对应

Type	IDs
Synonymous	ECK0232, dinP
Gene	UniProtKB-ID: DPO4_ECOLI UniprotKB: Q47155 UniParc: UPI0000129794 EMBL: AF483080, AF483088, AF483094, AF483090, AF483102, AF483084, AF483082, AF483101, AF483093, AF483081, AF483086, AF483098, AF483085, U00096, U70214, AF483091, AF483103, AF483099, AF483083, AF483089, D38582, AF483097, AF483100, AF483095, AP009048, AF483087, AF483096, AF483092, AF483104, AF483105 EnsemblGenome: b0231, BAA77901 KO: ecj:JW0221, eco:b0231
Nucleutide sequences	EMBL-CDS: AAL91959.1, AAL91946.1, AAL91965.1, AAL91951.1, AAL91953.1, BAA07593.1, AAL91964.1, AAL91944.1, AAL91968.1, AAL91954.1, AAL91958.1, AAB08651.1, AAL91945.1, AAL91962.1, AAL91950.1, AAL91963.1, AAL91952.1, AAL91948.1, AAL91956.1, AAL91943.1, AAL91949.1, BAA77901.1, AAL91957.1, AAC73335.1, AAL91961.1, AAL91967.1, AAL91960.1, AAL91947.1, AAL91966.1, AAL91955.1 EnsemblGenome_TRS: AAC73335, BAA77901
Protein sequencees	EnsemblGenome_PRO: BAA77901, AAC73335 RefSeq: NP_414766.1
Others	UniRef100: UniRef100_B1J100 UniRef90: UniRef90_Q8X7Q1 UniRef50: UniRef50_Q8X7Q1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
32687193	Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV inÂ double strand break repair. Nucleic Acids Res Sarah S Henrikus , Camille Henry , Amy E McGrath , Slobodan Jergic , John P McDonald , Yvonne Hellmich , Steven T Bruckbauer , Matthew L Ritger , Megan E Cherry , Elizabeth A Wood , Phuong T Pham , Myron F Goodman , Roger Woodgate , Michael M Cox , Antoine M van Oijen , Harshad Ghodke , Andrew Robinson	2020-09-04	-
30872406	Residues in the fingers domain of the translesion DNA polymerase DinB enable its unique participation in error-prone double-strand break repair. J Biol Chem Tommy F Tashjian , Claudia Danilowicz , Anne-Elizabeth Molza , Brian H Nguyen , Chantal PrÃ©vost , Mara Prentiss , Veronica G Godoy	2019-05-10	-
29351274	DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli. PLoS Genet Sarah S Henrikus , Elizabeth A Wood , John P McDonald , Michael M Cox , Roger Woodgate , Myron F Goodman , Antoine M van Oijen , Andrew Robinson	2018-01-01	-
28686598	Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli. PLoS Genet. RÃ©gine Janel-Bintz , Rita L Napolitano , Asako Isogawa , Shingo Fujii , Robert P Fuchs	2017-07-01	-
28727736	Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli. PLoS Genet Jessica M Moore , Raul Correa , Susan M Rosenberg , P J Hastings	2017-07-01	-
27280472	Mutations Affecting Potassium Import Restore the Viability of the Escherichia coli DNA Polymerase III holD Mutant. PLoS Genet. Adeline Durand , Anurag Kumar Sinha , Cloelia Dard-Dascot , BÃ©nÃ©dicte Michel	2016-06-01	-
25899385	Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase Îº. FEBS J. Philip Nevin , Xueguang Lu , Ke Zhang , John R Engen , Penny J Beuning	2015-07-01	dinB, POLK
25684709	Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change. DNA Repair (Amst.) Philip Nevin , John R Engen , Penny J Beuning	2015-05-01	dinB, POLK
24957605	DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts. Nucleic Acids Res. Mio Ikeda , Asako Furukohri , Gaelle Philippin , Edward Loechler , Masahiro Tatsumi Akiyama , Tsutomu Katayama , Robert P Fuchs , Hisaji Maki	2014-07-01	dinB
24657250	A ÎdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation. Mutat. Res. Mei-Chong W Lee , Magdalena Franco , Doris M Vargas , Deborah A Hudman , Steven J White , Robert G Fowler , Neil J Sargentini	2014-03-20	dinB

研究热度

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