| Type | Description |
|---|---|
| Definition | peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcB |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:14:00 | Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli. | 33196080 |
| 2020-08-12 11:02:00 | Upregulation of PBP1B and LpoB in cysB mutants confers mecillinam resistance in Escherichia coli. | 31332059 |
| 2019-06-01 12:37:00 | The lipoprotein LpoB is required to activate PBP1B, which is a major, bi-functional peptidoglycan synthase with glycan chain polymerising (glycosyltransferase) and peptide cross-linking (transpeptidase) activities. The authors show how the binding of LpoB to the regulatory UB2H domain of PBP1B activates both activities. | 30044025 |
| 2019-04-13 12:22:00 | The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB. | 30622193 |
| 2017-06-03 11:38:00 | crystal structures of E. coli PBP1b bound to multiple different beta-lactams in the transpeptidase active site and complement these data with gel-based competition assays to provide a detailed structural understanding of its inhibition. Taken together, these biochemical and structural data allow us to propose new insights into inhibition of both enzymatic domains in PBP1b. | 27899450 |
| Type | IDs |
|---|---|
| Synonymous | ECK0148, pbpF, ponB |
| Gene |
UniProtKB-ID:
PBPB_ECOLI
UniprotKB:
P02919
UniParc:
UPI0000168005,
UPI0000D7A4EB
EMBL:
U00096,
AP009048,
X02163
EnsemblGenome:
BAB96725,
b0149
KO:
ecj:JW0145,
eco:b0149
|
| Nucleutide sequences |
EMBL-CDS:
CAA26098.1,
CAA26099.1,
AAC73260.1,
BAB96725.2
EnsemblGenome_TRS:
BAB96725,
AAC73260
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73260,
BAB96725
RefSeq:
NP_414691.1
|
| Others |
UniRef100:
UniRef100_P02919
UniRef90:
UniRef90_P02919
UniRef50:
UniRef50_P02919
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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