murD - UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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944818 murD

基因描述

Type	Description
Definition	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

研究结论

Date	Results	Publications
2016-08-06 10:46:00	A detailed analysis provides insight into the events that lead to the closure of MurD and reveals that minor structural modifications contribute to major overall conformation alterations.	27031227
2010-01-21 00:00:00	Results report the high resolution crystal structures of MurD in complexes with two novel inhibitors designed to mimic the transition state of the reaction, which contain either the D-Glu or the L-Glu moiety.	17507028
2010-01-21 00:00:00	Evaluation of three possible reaction pathways leading to tetrahedral intermediate formation by MurD ligase.	18704940
2007-11-05 21:39:00	N-terminus verified by Edman degradation on mature peptide	1765076

名称对应

Type	IDs
Synonymous	ECK0089
Gene	UniProtKB-ID: MURD_ECOLI UniprotKB: P14900 UniParc: UPI000003EB64 EMBL: X55034, X17609, AP009048, M30807, U00096, X51584 EnsemblGenome: BAB96656, b0088 KO: ecj:JW0086, eco:b0088
Nucleutide sequences	EMBL-CDS: CAA35611.1, CAA38865.1, AAC73199.1, CAA35933.1, AAA83858.1, BAB96656.1 EnsemblGenome_TRS: BAB96656, AAC73199
Protein sequencees	EnsemblGenome_PRO: BAB96656, AAC73199 RefSeq: NP_414630.1
Others	UniRef100: UniRef100_P14900 UniRef90: UniRef90_P14900 UniRef50: UniRef50_P14900

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
27031227	Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited. PLoS ONE Roman Å ink , Miha Kotnik , Anamarija Zega , HÃ©lÃ¨ne Barreteau , Stanislav Gobec , Didier Blanot , AndrÃ©a Dessen , Carlos Contreras-Martel	2016-01-01	-
24561554	The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. Seesandra V Rajagopala , Patricia Sikorski , Ashwani Kumar , Roberto Mosca , James Vlasblom , Roland Arnold , Jonathan Franca-Koh , Suman B Pakala , Sadhna Phanse , Arnaud Ceol , Roman HÃ¤user , Gabriella Siszler , Stefan Wuchty , Andrew Emili , Mohan Babu , Patrick Aloy , Rembert Pieper , Peter Uetz	2014-03-01	-
24389752	Reconstitution of the peptidoglycan cytoplasmic precursor biosynthetic pathway in cell-free system and rapid screening of antisense oligonucleotides for Mur enzymes. Appl. Microbiol. Biotechnol. Jiayuan Sheng , Lei Huang , Xiangcheng Zhu , Jin Cai , Zhinan Xu	2014-02-01	-
19804894	Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg. Chem. Matej Sova , Andreja Kovac , Samo Turk , Martina Hrast , Didier Blanot , Stanislav Gobec	2009-12-01	murE, murF, murD, murC
19403924	New high-throughput fluorimetric assay for discovering inhibitors of UDP-N-acetylmuramyl-L-alanine: D-glutamate (MurD) ligase. J Biomol Screen Katja Kristan , Miha Kotnik , Marko Oblak , Uros Urleb	2009-04-01	murD
18704940	MurD ligase from E. coli: Tetrahedral intermediate formation study by hybrid quantum mechanical/molecular mechanical replica path method. Proteins Andrej Perdih , Milan Hodoscek , Tom Solmajer	2009-02-15	murD
19014883	Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase. Bioorg. Med. Chem. Lett. Tihomir TomasiÄ , Nace Zidar , Veronika Rupnik , Andreja Kovac , Didier Blanot , Stanislav Gobec , Danijel Kikelj , Lucija Peterlin Masic	2009-01-01	murD
19007109	Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem. Jan Humljan , Miha Kotnik , Carlos Contreras-Martel , Didier Blanot , Uros Urleb , AndrÃ©a Dessen , Tom Solmajer , Stanislav Gobec	2008-12-11	murD
18651694	Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases. ChemMedChem Roman Sink , Andreja Kovac , Tihomir TomasiÄ , Veronika Rupnik , Audrey Boniface , Julieanne Bostock , Ian Chopra , Didier Blanot , Lucija Peterlin Masic , Stanislav Gobec , Anamarija Zega	2008-09-01	murD, murC
18259126	Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents. Molecules Rok Frlan , Andreja Kovac , Didier Blanot , Stanislav Gobec , Slavko Pecar , Ales Obreza	2008-01-11	-

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