| Type | Description |
|---|---|
| Definition | dihydrofolate reductase |
| Date | Results | Publications |
|---|---|---|
| 2019-04-06 10:16:00 | Mutational and computational analyses in EcDHFR and in DHFR enzymes from Staphylococcus aureus and Mycobacterium tuberculosis demonstrate that natural variation at this site and its interacting hydrophobic residues modulates trimethoprim resistance in other bacterial DHFRs as well | 29871875 |
| 2015-08-29 10:31:00 | NADP+ not only binds to the native form but also a partially unfolded form of dihydrofolate reductase. | 25367157 |
| 2014-02-15 11:58:00 | Quantum mechanics/molecular dynamics simulations reveal that the M20 loop conformational dynamics of dihydrofolate reductase (DHFR) is severely restricted at the transition state of the hydride transfer as a result of the M42W/G121V double mutation. | 23297871 |
| 2014-02-08 12:28:00 | Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle | 23614825 |
| 2013-09-07 10:39:00 | The data presented here provide a glimpse into the evolutionary trajectory of functional DHFR through its protein sequence space that lead to the diverged binding and catalytic properties of the E. coli and human enzymes. | 23733948 |
| Type | IDs |
|---|---|
| Synonymous | ECK0049, tmr, tmrA |
| Gene |
UniProtKB-ID:
DYR_ECOLI
UniprotKB:
P0ABQ4
UniParc:
UPI0000110F69
EMBL:
X05108,
J01609,
U00096,
AP009048
EnsemblGenome:
BAB96616,
b0048
KO:
eco:b0048,
ecj:JW0047
|
| Nucleutide sequences |
EMBL-CDS:
CAA28755.1,
BAB96616.1,
AAC73159.1,
AAA87976.1
EnsemblGenome_TRS:
BAB96616,
AAC73159
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73159,
BAB96616
RefSeq:
NP_414590.1
|
| Others |
UniRef100:
UniRef100_P0ABQ5
UniRef90:
UniRef90_P0ABQ5
UniRef50:
UniRef50_P0ABQ5
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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