| Type | Description |
|---|---|
| Definition | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase |
| Date | Results | Publications |
|---|---|---|
| 2018-07-14 11:13:00 | work for the first time identified HMBPP to be a cytotoxic intermediate in MEP pathway and demonstrated that balanced activation of IspG and IspH could eliminate accumulation of HMBPP and MECPP and improve isoprenoids production. | 28864262 |
| 2013-02-09 10:58:00 | IspH can hydrate acetylenes to aldehydes and ketones via anti-Markovnikov/Markovnikov addition. | 22948824 |
| 2010-01-21 00:00:00 | In LytB an unusual [4Fe-4S](2+) cluster is attached to the protein by three conserved cysteines and contains a hexacoordinated iron linked to three sulfurs of the cluster and three additional oxygen or nitrogen ligands. | 19708647 |
| 2010-01-21 00:00:00 | a structure-based rationale of the substrate binding mode of ispH, which in combination with mutational studies and theoretical calculation supports a reaction mechanism representing a biological counterpart of the Birch reduction of allylic alcohols. | 19569147 |
| Type | IDs |
|---|---|
| Synonymous | ECK0030, lytB, yaaE |
| Gene |
UniProtKB-ID:
ISPH_ECOLI
UniprotKB:
P62623
UniParc:
UPI00000541D2
EMBL:
AY062212,
U00096,
X54945,
AP009048
EnsemblGenome:
b0029,
BAB96598
KO:
eco:b0029,
ecj:JW0027
|
| Nucleutide sequences |
EMBL-CDS:
AAC73140.1,
AAL38655.1,
CAA38707.1,
BAB96598.1
EnsemblGenome_TRS:
AAC73140,
BAB96598
|
| Protein sequencees |
EnsemblGenome_PRO:
BAB96598,
AAC73140
RefSeq:
NP_414570.1
|
| Others |
UniRef100:
UniRef100_A7ZHB8
UniRef90:
UniRef90_A7MIM0
UniRef50:
UniRef50_Q6D0C6
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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