| Type | Description |
|---|---|
| Definition | steroid 5 alpha-reductase 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-16 12:19:00 | Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice | 28493878 |
| 2010-01-21 00:00:00 | The induction of Srd5a2 through SREBP-2 provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies. | 19500568 |
| 2010-01-21 00:00:00 | observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes | 15860270 |
| 2010-01-21 00:00:00 | molecular cloning & transcriptional activation of the gene | 11884637 |
| Type | IDs |
|---|---|
| Synonymous | 5ART2, S5AR 2 |
| Gene |
UniProtKB-ID:
S5A2_MOUSE
UniprotKB:
Q99N99
UniParc:
UPI000002594E
EMBL:
BC125510,
AK138946,
AB049456
Ensembl:
ENSMUSG00000038541
KO:
mmu:94224
|
| Nucleutide sequences |
EMBL-CDS:
AAI25511.1,
BAE23830.1,
BAB40179.1
Ensembl_TRS:
ENSMUST00000043458
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000048862
RefSeq:
NP_444418.1
|
| Others |
UniRef100:
UniRef100_Q99N99
UniRef90:
UniRef90_P31214
UniRef50:
UniRef50_P31214
UniGene:
Mm.38933
CCDS:
CCDS28968.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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