| Type | Description |
|---|---|
| Definition | heart and neural crest derivatives expressed 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 13:00:00 | Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. | 27297109 |
| 2017-04-01 11:18:00 | association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot | 27942761 |
| 2017-03-18 13:19:00 | These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV. | 28112363 |
| 2017-03-04 12:53:00 | HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. | 26581070 |
| 2016-04-02 11:23:00 | Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. | 25050861 |
| Type | IDs |
|---|---|
| Synonymous | Hxt, Thing1, bHLHa27, eHand |
| Gene |
UniProtKB-ID:
HAND1_HUMAN
UniprotKB:
O96004
UniParc:
UPI000012C083
EMBL:
AF061756,
AF063012,
BC021190
Ensembl:
ENSG00000113196
KO:
hsa:9421
|
| Nucleutide sequences |
EMBL-CDS:
AAD19283.1,
AAD19280.1,
AAH21190.1
Ensembl_TRS:
ENST00000231121
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000231121
RefSeq:
XP_005268588.1,
NP_004812.1
|
| Others |
UniRef100:
UniRef100_O96004
UniRef90:
UniRef90_Q64279
UniRef50:
UniRef50_Q64279
UniGene:
Hs.152531
CCDS:
CCDS4327.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32814053 |
Cell Rep Christian Haenig , Nir Atias , Alexander K Taylor , Arnon Mazza , Martin H Schaefer , Jenny Russ , Sean-Patrick Riechers , Shushant Jain , Maura Coughlin , Jean-Fred Fontaine , Brian D Freibaum , Lydia Brusendorf , Martina Zenkner , Pablo Porras , Martin Stroedicke , Sigrid Schnoegl , Kristin Arnsburg , Annett Boeddrich , Lucia Pigazzini , Peter Heutink , J Paul Taylor , Janine Kirstein , Miguel A Andrade-Navarro , Roded Sharan , Erich E Wanker |
2020-08-18 | - |
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 28112363 |
HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle. Int. J. Mol. Med. Li Li , Juan Wang , Xing-Yuan Liu , Hua Liu , Hong-Yu Shi , Xiao-Xiao Yang , Ning Li , Yan-Jie Li , Ri-Tai Huang , Song Xue , Xing-Biao Qiu , Yi-Qing Yang |
2017-03-01 | - |
| 27942761 |
HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot. Pediatr Cardiol Juan Wang , Xiao-Qing Hu , Yu-Han Guo , Jian-Yun Gu , Jia-Hong Xu , Yan-Jie Li , Ning Li , Xiao-Xiao Yang , Yi-Qing Yang |
2017-03-01 | - |
| 27297109 |
Hand1 overexpression inhibits medulloblastoma metastasis. Biochem. Biophys. Res. Commun. Swapna Asuthkar , Maheedhara R Guda , Sarah E Martin , Reuben Antony , Karen Fernandez , Julian Lin , Andrew J Tsung , Kiran K Velpula |
2016-08-19 | - |
| 26581070 |
HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy. Clin. Chem. Lab. Med. Yi-Meng Zhou , Xiao-Yong Dai , Xing-Biao Qiu , Fang Yuan , Ruo-Gu Li , Ying-Jia Xu , Xin-Kai Qu , Ri-Tai Huang , Song Xue , Yi-Qing Yang |
2016-07-01 | - |
| 25609649 |
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. Xu Li , Wenqi Wang , Jiadong Wang , Anna Malovannaya , Yuanxin Xi , Wei Li , Rudy Guerra , David H Hawke , Jun Qin , Junjie Chen |
2015-01-01 |
ABI1,
ZBTB33,
TCF24,
RPL29P11,
FOXO6,
HDAC6,
HDAC5,
MEF2B,
CHAF1A,
PARP2,
HMGXB4,
SMC4,
FARSB,
HUWE1,
RAD50,
SUGP2,
ABI2,
WASF2,
ALYREF,
TSHZ1,
DDX39A,
TRIB1,
GPHN,
AKAP8,
STAG1,
SF3A1,
TNIP1,
ADAR,
HMG20B,
IRF9,
MYL12B,
MYL9,
CFDP1,
MCRS1,
TOMM40,
CDX2,
COG5,
HOXB13,
LRRC41,
NCOA2,
CEBPB,
KAT5,
SLU7,
DRAP1,
SMC2,
CENPB,
PRPF8,
MXD4,
P3H4,
TRIM3,
ARID3B,
STAG2,
NCKAP1,
IQGAP2,
ZNF268,
UTP14A,
MRPS30,
BRD8,
TCERG1,
MORF4,
POP1,
SF3A3,
SF3B2,
KIF2C,
ATF7,
TMED1,
RCC1,
DDX52,
CHD4,
FOXN3,
PSIP1,
WDHD1,
CHI3L2,
BAZ1A,
NISCH,
CHEK2,
MRPL3,
PNKP,
SGF29,
NACC1,
ACOT7,
LACTB,
DNTTIP1,
FOXP4,
IKBIP,
JDP2,
ANKRD26P1,
HEXIM2,
C17orf49,
NDUFA11,
PUSL1,
COPA,
MAP3K8,
LIN54,
C5orf24,
COX7A2,
CPOX,
CPS1,
NACC2
|
| 25035420 |
Hum. Mol. Genet. Kyung-Won Hong , Ji Eun Lim , Jong Wook Kim , Yasuharu Tabara , Hirotsugu Ueshima , Tetsuro Miki , Fumihiko Matsuda , Yoon Shin Cho , Yeonjung Kim , Bermseok Oh |
2014-12-15 |
LOC101929667,
CDKN1A,
SETBP1,
SCN5A,
SCN10A,
PRDM16,
GAREM1,
SLC8A1,
TBX5,
TBX3,
SAP30L,
CAV1,
CAV2,
PRDM6,
HAND1,
EXOG
|
| 24952347 |
Biochimie Romain Pacaud , Quentin Sery , Lisa Oliver , François M Vallette , Jörg Tost , Pierre-François Cartron |
2014-09-01 |
HEY,
CDX2,
GMEB1,
KLF12,
CREB1,
ATF2,
CREBL2,
CREM,
DDIT3,
AES,
DLX4,
DNMT3A,
DNMT3B,
DR1,
E2F3,
E2F4,
E2F5,
E2F6,
EGR1,
EGR2,
EGR4,
ESR1,
ESR2,
ESRRG,
ETS1,
F2RL1,
FOS,
FOSB,
FOSL2,
GATA1,
NR6A1,
NR3C1,
GTF2H2,
GTF2I,
DNMT3L,
HNF4G,
HOXA5,
HOXC11,
ID1,
JUN,
JUNB,
SMAD1,
SMAD3,
SMAD4,
MAX,
MECP2,
MEF2A,
MEF2D,
ATF1,
ATF3,
ATF4,
NFIL3,
NFKB1,
PAX6,
RELA,
RXRA,
NR2E1,
TP53,
TRAF1,
NR1H2,
YY1,
MAFK,
FOSL1,
BLZF1,
NR1I2,
LDB1,
ASH2L,
GTF3C5,
LHX2,
HAND1,
MED7,
HAND2,
NR1I3,
DMTF1
|
| 24623737 |
Mol Cancer Ther Swapna Asuthkar , Venkateswara Rao Gogineni , Jasti S Rao , Kiran Kumar Velpula |
2014-05-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员