| Type | Description |
|---|---|
| Definition | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 12:14:00 | pancreas-specific conditional KO of C1galt1 expression of truncated O-glycans, which in turn accelerates Pancreatic ductal adenocarcinomas (PDACs) progression and metastasis. | 30086262 |
| 2018-05-26 10:35:00 | hepatic asialoglycoprotein receptor promotes preferential adherence to and phagocytosis of desialylated and/or HC C1galt1(-/-) platelets by the Kupffer cell through its C-type lectin receptor CLEC4F. These findings provide insights into an essential role for core 1 O-glycosylation of platelets in their clearance in the liver. | 28716912 |
| 2017-09-02 10:22:00 | Deletion of C1galt1 in mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course due to loss of mucin core-1 derived O-glycans. | 27874308 |
| 2015-11-14 10:24:00 | C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity. | 25089569 |
| 2013-12-07 11:23:00 | O-glycan is required for terminal megakaryocyte differentiation and platelet production and the decrease in GPIbalpha in cells lacking O-glycan might be caused by increased proteolysis. | 23794065 |
| Type | IDs |
|---|---|
| Synonymous | 2210410E06Rik, AV284120, T-synthase |
| Gene |
UniProtKB-ID:
C1GLT_MOUSE
UniprotKB:
Q9JJ06
UniParc:
UPI0000024D47
EMBL:
BC025899,
AF157962,
BC064767
Ensembl:
ENSMUSG00000042460
KO:
mmu:94192
|
| Nucleutide sequences |
EMBL-CDS:
AAH64767.1,
AAF81982.1,
AAH25899.1
Ensembl_TRS:
ENSMUST00000040159
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047931
RefSeq:
NP_443719.3
|
| Others |
UniRef100:
UniRef100_Q9JJ06
UniRef90:
UniRef90_Q9JJ06
UniRef50:
UniRef50_Q9NS00
UniGene:
Mm.102752,
Mm.482425
CCDS:
CCDS19908.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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