| Type | Description |
|---|---|
| Definition | oligophrenin 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-02 12:12:00 | Ophn1 deficiency generates severe impairments in performance at spatial working memory tests. | 29030432 |
| 2017-09-30 10:29:00 | Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment | 27146843 |
| 2017-07-29 12:44:00 | Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets. | 27742778 |
| 2017-02-25 12:10:00 | OPHN1 mediated regulation of RhoA, Rac1 and Cdc42 is crucial for the preservation of cardiac function after myocardial injury. | 27117132 |
| 2016-02-13 10:17:00 | Identify OPHN1 as an important regulator of platelet cytoskeletal reorganization and thrombus formation. | 25556321 |
| Type | IDs |
|---|---|
| Synonymous | C130037N19Rik, Wtgr |
| Gene |
UniProtKB-ID:
OPHN1_MOUSE,
Q8CA59_MOUSE
UniprotKB:
Q99J31,
Q8CA59
UniParc:
UPI00000E9679,
UPI0000003FB2
EMBL:
AK039556,
BC004845,
AK087469,
AK031419,
AK036038
Ensembl:
ENSMUSG00000031214
KO:
mmu:94190
|
| Nucleutide sequences |
EMBL-CDS:
BAC39887.1,
AAH04845.1,
BAC27395.1,
BAC29282.1,
BAC30381.1
Ensembl_TRS:
ENSMUST00000033560,
ENSMUST00000113826
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033560,
ENSMUSP00000109457
RefSeq:
XP_011245995.1,
NP_001300683.1,
XP_011245996.1,
NP_001300685.1,
NP_443208.1,
NP_001300684.1,
XP_036018024.1
|
| Others |
UniRef100:
UniRef100_Q8CA59,
UniRef100_Q99J31
UniRef90:
UniRef90_O60890,
UniRef90_Q8CA59
UniRef50:
UniRef50_O60890,
UniRef50_Q8CA59
UniGene:
Mm.254336
CCDS:
CCDS30295.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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