| Type | Description |
|---|---|
| Definition | dedicator of cyto-kinesis 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 13:13:00 | The regulation of the actin dynamics by DOCK2 enhances the threshold for entry into the virtual memory compartment by negatively regulating tonic TCR triggering in response to weak agonists. | 31740487 |
| 2020-06-20 10:29:00 | this study has provided a novel underlying molecular mechanism of how DOCK2 deficiency regulates surface expression of CD21, which leads to downregulation of CD19-mediated BCR signaling and marginal zone B-cell differentiation | 31405607 |
| 2019-10-19 11:37:00 | Study identified cholesterol sulfate as a naturally occurring DOCK2 inhibitor that binds to the catalytic DHR-2 domain and blocks its Rac GEF activity. | 30065028 |
| 2019-07-06 13:04:00 | findings highlight the effects of confounding mutations from widely used inbred strains on gene-targeted mice and reveal new functions of DOCK2 in B cells. | 30012848 |
| 2019-03-30 11:53:00 | Study found that B cell receptor-mediated Rac activation and immunological synapses formation critically depend on Dock2. By analyzing three different models, study demonstrated that Dock2 expression in B-lineage cells is required for plasma cells differentiation and antigen-specific IgG production. | 29503648 |
| Type | IDs |
|---|---|
| Synonymous | AI662014, AW122239, CED-5, Hch, MBC |
| Gene |
UniProtKB-ID:
DOCK2_MOUSE,
Q6A0A3_MOUSE
UniprotKB:
Q8C3J5,
Q6A0A3
UniParc:
UPI00003FEEEA,
UPI0000192B07
EMBL:
AY027438,
AL671971,
AL669849,
AK085708,
CR762384,
AK172915,
CR392356
Ensembl:
ENSMUSG00000020143
KO:
mmu:94176
|
| Nucleutide sequences |
EMBL-CDS:
BAC39514.2,
AAK13045.1,
BAD32193.1
Ensembl_TRS:
ENSMUST00000093193
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000090884
RefSeq:
NP_203538.2,
XP_017170351.1
|
| Others |
UniRef100:
UniRef100_Q8C3J5
UniRef90:
UniRef90_Q8C3J5
UniRef50:
UniRef50_Q8C3J5
UniGene:
Mm.380679
CCDS:
CCDS83791.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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