| Type | Description |
|---|---|
| Definition | GRB2 related adaptor protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-16 11:02:00 | These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. | 28289074 |
| 2017-06-03 12:19:00 | Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity | 27927989 |
| 2015-12-26 11:39:00 | GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 and PLC-gamma1 phosphorylation but exhibited substantial decrease in TCR-induced IL-2 and IFN-gamma release. | 25636200 |
| 2015-08-15 10:09:00 | Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression. | 25452106 |
| 2013-10-26 14:05:00 | GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates. | 23399893 |
| Type | IDs |
|---|---|
| Synonymous | GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38 |
| Gene |
UniProtKB-ID:
GRAP2_HUMAN,
B7Z8E3_HUMAN,
Q6FI14_HUMAN
UniprotKB:
O75791,
B7Z8E3,
Q6FI14
UniParc:
UPI000012BB02,
UPI000191509E,
UPI00019152CD
EMBL:
AF042380,
BC026002,
AF129476,
AF121002,
AK303470,
AJ011736,
Y18051,
AF236119,
AK312830,
AF102694,
AK303280,
AF090456,
AF236120,
BC025692,
CH471095,
CR536524,
Z82206,
AY069959,
CR456498
Ensembl:
ENSG00000100351
KO:
hsa:9402
|
| Nucleutide sequences |
EMBL-CDS:
AAC69273.1,
BAH13969.1,
AAH25692.1,
CAA77021.1,
AAF60320.1,
AAF31758.1,
CAA09757.1,
AAH26002.1,
AAD04926.1,
AAF60319.1,
CAG30384.1,
AAD41782.1,
AAD13027.1,
AAL58573.1,
BAH13929.1,
CAG38761.1,
EAW60356.1,
EAW60359.1,
BAG35685.1
Gene_ORFName:
hCG_41723
Ensembl_TRS:
ENST00000407075,
ENST00000344138
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385607,
ENSP00000339186
RefSeq:
NP_001278755.1,
NP_001278753.1,
NP_004801.1,
XP_006724439.1,
NP_001278754.1,
NP_001278757.1
|
| Others |
UniRef100:
UniRef100_O75791
UniRef90:
UniRef90_O75791
UniRef50:
UniRef50_O75791
UniGene:
Hs.517499
CCDS:
CCDS13999.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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