| Type | Description |
|---|---|
| Definition | RecQ like helicase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-26 13:15:00 | Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution. | 33046774 |
| 2020-09-19 16:31:00 | Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase. | 32432680 |
| 2020-07-25 12:37:00 | we analyzed 5562 children with cancer and identified a significant enrichment of heterozygous RECQL4 loss-of-function (LOF) variants in patients with ossteosarcoma. Notably, most children carried the same RECQL4 alteration: c.1573delT (p.Cys525Alafs), which is predicted to truncate the RECQL4 protein within its DNA helicase domain. RECQL4 LOF variants were rarely observed in children with other cancer types | 31604778 |
| 2020-07-25 10:15:00 | Results suggest that recruitment of RecQL4 to replication origins is an important step for temporal activation of replication origins during S phase. Further, perturbation of replication timing control by unscheduled origin activation significantly induces replication stress, which is mostly caused by transcription-replication conflicts. | 31519754 |
| 2020-02-29 10:09:00 | RECQL4 down-regulation in HeLa cells causes chromosome misalignment and delays mitotic progression, and defects in mitotic chromosome alignment might be a contributing factor for the Rothmund-Thomson syndrome. | 30718377 |
| Type | IDs |
|---|---|
| Synonymous | RECQ4 |
| Gene |
UniProtKB-ID:
RECQ4_HUMAN
UniprotKB:
O94761
UniParc:
UPI0000E5E124
EMBL:
AB006532,
BC011602,
KF495717,
AB026546,
AC084125,
BC013277,
DQ176868
Ensembl:
ENSG00000160957
KO:
hsa:9401
|
| Nucleutide sequences |
EMBL-CDS:
BAA86899.1,
BAA74453.1,
AAH13277.2,
AAH11602.2,
AAZ85145.1
Ensembl_TRS:
ENST00000617875
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000482313
RefSeq:
XP_016869488.1,
XP_016869481.1,
XP_011515686.1,
XP_016869483.1,
XP_016869480.1,
NP_004251.4,
XP_016869489.1,
XP_016869486.1,
XP_016869490.1,
XP_016869484.1,
XP_016869482.1,
XP_016869487.1,
XP_016869485.1
|
| Others |
UniRef100:
UniRef100_O94761
UniRef90:
UniRef90_O94761
UniRef50:
UniRef50_O94761
UniGene:
Hs.31442
CCDS:
CCDS75804.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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