| Type | Description |
|---|---|
| Definition | heparan sulfate 6-O-sulfotransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 12:37:00 | We have linked a deleterious mutation in HS6ST1 to familial self-limited delayed puberty and show that heterozygous Hs6st1 loss causes delayed puberty in mice. In this study, the observed overlap in potentially pathogenic mutations contributing to the phenotypes of self-limited delayed puberty and hypogonadotropic hypogonadism was limited to this one gene. | 29931354 |
| 2018-07-07 10:16:00 | RT-PCR analysis showed that the overall transcriptional activity of the main Heparan Sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) was decreased by 1.5-2-fold in Grade II-III glioma. | 29104277 |
| 2014-06-21 11:11:00 | HS6ST-1 and HS6ST-2 have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF signaling and subsequent expression of angiogenic cytokines by cancer cells | 24563483 |
| 2014-04-05 10:56:00 | Hs6st1 and Hs2st generate conditions conducive to corpus callosum development. | 24501377 |
| 2011-09-24 10:58:00 | idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development | 21700882 |
| Type | IDs |
|---|---|
| Synonymous | HH15, HS6ST |
| Gene |
UniProtKB-ID:
H6ST1_HUMAN
UniprotKB:
O60243
UniParc:
UPI0000D61231,
UPI00017A70E7
EMBL:
AC017079,
BC099638,
AB006179,
BC096239,
AK295898,
AK293724,
BC099639,
BC096240,
BC001196
Ensembl:
ENSG00000136720
KO:
hsa:9394
|
| Nucleutide sequences |
EMBL-CDS:
AAH01196.1,
AAH96239.4,
BAG58691.1,
AAY14736.1,
AAH99639.4,
AAH96240.4,
BAA25760.1,
AAH99638.4,
BAG57153.1
Ensembl_TRS:
ENST00000259241
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259241
RefSeq:
NP_004798.3
|
| Others |
UniRef100:
UniRef100_O60243
UniRef90:
UniRef90_O60243
UniRef50:
UniRef50_O60243
UniGene:
Hs.512841
CCDS:
CCDS42748.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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