gabR - transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)-BMKCloudï½ç¾è¿å®¢äº

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938271 gabR

基因描述

Type	Description
Definition	transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)

研究结论

Date	Results	Publications
2021-01-16 15:55:00	(S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR.	32557944
2017-06-24 11:36:00	One subunit is a closed-form containing the PLP-GABA adduct, and the other subunit is a PLP-bound open-form. Our structural studies provide a detailed mechanism indicating that the open-to-closed transition by the binding of GABA induces the conformational rearrangement of BsGabR-CTD, which may trigger the activation of transcription.	28412355
2016-07-16 11:26:00	Data show that DNA undergoes a conformational change to bend around transcription factor GabR during binding.	26681693
2016-06-28 10:43:00	These results suggested that each domain of GabR could be an independent folding unit. The C-terminal domain provides the N-terminal domain with DNA-binding ability via dimerization.	25911692
2015-08-22 11:13:00	study examined the mechanism underlying GabR-mediated gabTD transcription, focusing on the function of the aminotransferase domain.	25388514

名称对应

Type	IDs
Synonymous	BSU03890
Gene	UniProtKB-ID: GABR_BACSU, A0A6M4JFH9_BACSU UniprotKB: P94426, A0A6M4JFH9 UniParc: UPI000005FF28 EMBL: CP053102, CP052842, AL009126, D50453 EnsemblGenome: BSU03890 KO: bsu:BSU03890
Nucleutide sequences	EMBL-CDS: BAA09020.1, CAB12197.1, QJP86929.1, QJR44846.1 Gene_ORFName: HIR77_02225, HIR78_02245 EnsemblGenome_TRS: CAB12197
Protein sequencees	EnsemblGenome_PRO: CAB12197 RefSeq: NP_388271.1
Others	UniRef100: UniRef100_P94426 UniRef90: UniRef90_P94426 UniRef50: UniRef50_P94426

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32557944	(S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR. Protein Sci Daniel S Catlin , Cory T Reidl , Thomas R Trzupek , Richard B Silverman , Brian L Cannon , Daniel P Becker , Dali Liu	2020-08-01	-
29280348	Bacillus subtilis, the model Gram-positive bacterium: 20Â years of annotation refinement. Microb Biotechnol Rainer Borriss , Antoine Danchin , Colin R Harwood , Claudine MÃ©digue , Eduardo P C Rocha , Agnieszka Sekowska , David Vallenet	2018-01-01	-
28412355	Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by Î³-aminobutyric acid binding, inducing transcriptional activation. Biochem. Biophys. Res. Commun. Seong Ah Park , Ye Song Park , Ki Seog Lee	2017-05-27	-
26681693	Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site. Nucleic Acids Res. Walid A Al-Zyoud , Robert Mg Hynson , Lorraine A Ganuelas , Adelle Cf Coster , Anthony P Duff , Matthew Ab Baker , Alastair G Stewart , Eleni Giannoulatou , Joshua Wk Ho , Katharina Gaus , Dali Liu , Lawrence K Lee , Till BÃ¶cking	2016-02-18	-
25911692	Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. J. Biochem. Keita Okuda , Tomokazu Ito , Masaru Goto , Takashi Takenaka , Hisashi Hemmi , Tohru Yoshimura	2015-09-01	-
25388514	Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. Mol. Microbiol. Keita Okuda , Shiro Kato , Tomokazu Ito , Shunsuke Shiraki , Yumiko Kawase , Masaru Goto , Susumu Kawashima , Hisashi Hemmi , Harumi Fukada , Tohru Yoshimura	2015-01-01	gabR
23429746	An updated metabolic view of the Bacillus subtilis 168 genome. Microbiology (Reading, Engl.) Eugeni Belda , Agnieszka Sekowska , FranÃ§ois Le FÃ¨vre , Anne Morgat , Damien Mornico , Christos Ouzounis , David Vallenet , Claudine MÃ©digue , Antoine Danchin	2013-04-01	-
19383706	From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Microbiology (Reading) ValÃ©rie Barbe , StÃ©phane Cruveiller , Frank Kunst , Patricia Lenoble , Guillaume Meurice , Agnieszka Sekowska , David Vallenet , Tingzhang Wang , Ivan Moszer , Claudine MÃ©digue , Antoine Danchin	2009-06-01	-
9384377	The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature F Kunst , N Ogasawara , I Moszer , A M Albertini , G Alloni , V Azevedo , M G Bertero , P BessiÃ¨res , A Bolotin , S Borchert , R Borriss , L Boursier , A Brans , M Braun , S C Brignell , S Bron , S Brouillet , C V Bruschi , B Caldwell , V Capuano , N M Carter , S K Choi , J J Cordani , I F Connerton , N J Cummings , R A Daniel , F Denziot , K M Devine , A DÃ¼sterhÃ¶ft , S D Ehrlich , P T Emmerson , K D Entian , J Errington , C Fabret , E Ferrari , D Foulger , C Fritz , M Fujita , Y Fujita , S Fuma , A Galizzi , N Galleron , S Y Ghim , P Glaser , A Goffeau , E J Golightly , G Grandi , G Guiseppi , B J Guy , K Haga , J Haiech , C R Harwood , A HÃ¨naut , H Hilbert , S Holsappel , S Hosono , M F Hullo , M Itaya , L Jones , B Joris , D Karamata , Y Kasahara , M Klaerr-Blanchard , C Klein , Y Kobayashi , P Koetter , G Koningstein , S Krogh , M Kumano , K Kurita , A Lapidus , S Lardinois , J Lauber , V Lazarevic , S M Lee , A Levine , H Liu , S Masuda , C MauÃ«l , C MÃ©digue , N Medina , R P Mellado , M Mizuno , D Moestl , S Nakai , M Noback , D Noone , M O'Reilly , K Ogawa , A Ogiwara , B Oudega , S H Park , V Parro , T M Pohl , D Portelle , S Porwollik , A M Prescott , E Presecan , P Pujic , B Purnelle , G Rapoport , M Rey , S Reynolds , M Rieger , C Rivolta , E Rocha , B Roche , M Rose , Y Sadaie , T Sato , E Scanlan , S Schleich , R Schroeter , F Scoffone , J Sekiguchi , A Sekowska , S J Seror , P Serror , B S Shin , B Soldo , A Sorokin , E Tacconi , T Takagi , H Takahashi , K Takemaru , M Takeuchi , A Tamakoshi , T Tanaka , P Terpstra , A Togoni , V Tosato , S Uchiyama , M Vandebol , F Vannier , A Vassarotti , A Viari , R Wambutt , H Wedler , T Weitzenegger , P Winters , A Wipat , H Yamamoto , K Yamane , K Yasumoto , K Yata , K Yoshida , H F Yoshikawa , E Zumstein , H Yoshikawa , A Danchin	1997-11-20	yozQ, sspN, antE, mrpE, sboX, spsL, kipA, ygaF, sspG, ruvB, sda, sspK, yqzJ, yneP, ygzB, gerT, yojG, dgcW, sspL, ymzD, yezE, sspJ, yrzL, yizA, sspM, ydzU, ykzN, yqzK, yczK, yyzN, yoyI, youA, yezF, skfC, yjzI, rsoA, bsdD, ydzP, yxzL, yczO, yrzR, ykzL, yizB, yyzM, ykzW, ypzJ, yozS, ynzL, ygzC, ybzH, ykzS, yoyG, ytzI, yfzA, yojW, ypzF, epsK, yuzM, yuzL, yqzO, yszA, yczN, yyzH, yrzQ, ydzK, ypzH, yozT, yozV, ykzT, yizD, yoyC, yokU, mstX, yngHB, ylzI, ywzH, yoyF, spoVAEB, ynzK, spoVAEA, yhzD, yjzJ, yvzG, ytzJ, ydzQ, ykzU, fadG, yrzO, ylzH, yczL, yuzJ, ykzP, ypzI, ypzG, yuzI, yozY, yezG, ytrH, yozX

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