| Type | Description |
|---|---|
| Definition | solute carrier family 22 member 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:05:00 | Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. | 31691080 |
| 2020-02-22 13:00:00 | results indicate an increased alpha-ketoglutarate efflux by OAT1 and OAT3, resulting in a metabolic shift towards an oxidative phenotype | 30653465 |
| 2020-02-15 10:54:00 | these results provided first demonstration that Senp2 is a significant regulator for OAT3-mediated organic anion/drug transport | 31054272 |
| 2020-02-15 10:04:00 | Study demonstrated for the first time that stimulated OAT3 expression and transport activity by altering the trafficking kinetics of OAT3 possibly through the crosstalk between SUMOylation and ubiquitination. OAT3 is subjected to post-translational modification by SUMO-2 and SUMO-3 not by SUMO-1. | 30761470 |
| 2019-09-14 11:44:00 | Endogenous metabolite-mediated communication between OAT1/OAT3 and OATP1B1 may explain the association between SLCO1B1 SNPs and methotrexate toxicity. | 29285751 |
| Type | IDs |
|---|---|
| Synonymous | OAT3 |
| Gene |
UniProtKB-ID:
S22A8_HUMAN,
B2R807_HUMAN
UniprotKB:
Q8TCC7,
B2R807
UniParc:
UPI000175054C,
UPI0000036DF2,
UPI0000ED8FC1,
UPI0000DFFBA8,
UPI00001FA9EC,
UPI000041B909
EMBL:
AB042505,
AK298341,
AB209692,
AF097491,
AP001858,
BC022387,
AK313187
Ensembl:
ENSG00000149452
KO:
hsa:9376
|
| Nucleutide sequences |
EMBL-CDS:
BAB47393.1,
AAD19357.1,
AAH22387.1,
BAD92929.1,
BAG60589.1,
BAG36004.1
Ensembl_TRS:
ENST00000535878,
ENST00000336232,
ENST00000430500,
ENST00000545207
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000441658,
ENSP00000337335,
ENSP00000443368,
ENSP00000398548
RefSeq:
NP_001171661.1,
NP_001171662.1,
XP_011543666.1,
NP_001171665.1,
NP_004245.2
|
| Others |
UniRef100:
UniRef100_Q8TCC7,
UniRef100_B2R807
UniRef90:
UniRef90_Q8TCC7
UniRef50:
UniRef50_Q8TCC7
UniGene:
Hs.266223
CCDS:
CCDS53644.1,
CCDS53643.1,
CCDS8042.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员