| Type | Description |
|---|---|
| Definition | diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:48:00 | DisA may preserve genome integrity by downregulating RecA activities at several steps of the DNA damage tolerance pathway, allowing time for the repair machineries to restore genome stability | 30916351 |
| 2017-08-12 10:56:00 | DisA moving along dsDNA indicates absence of DNA damage/replication stress via normal c-di-AMP levels, while interaction with Holliday junction DNA/halted forks leads to reduced c-di-AMP levels and an ensuing block in cell proliferation. RadA/Sms may be involved in modulating DisA activities. | 28511132 |
| 2015-07-04 11:34:00 | c-di-AMP is a crucial signalling molecule involved in DNA repair with two diadenylate cyclases, DisA (YbbP) and CdaA (DacA), contributing to modulate different DNA damage responses during exponential growth in Bacillus subtilis cells. | 25616256 |
| Type | IDs |
|---|---|
| Synonymous | BSU00880 |
| Gene |
UniProtKB-ID:
DISA_BACSU,
A0A6M3Z6M0_BACSU
UniprotKB:
P37573,
A0A6M3Z6M0
UniParc:
UPI000005FE05
EMBL:
CP053102,
D26185,
AL009126,
CP052842
EnsemblGenome:
BSU00880
KO:
bsu:BSU00880
|
| Nucleutide sequences |
EMBL-CDS:
BAA05322.1,
CAB11864.1,
QJP86636.1,
QJR44550.1
Gene_ORFName:
HIR77_00585,
HIR78_00585
EnsemblGenome_TRS:
CAB11864
|
| Protein sequencees |
EnsemblGenome_PRO:
CAB11864
RefSeq:
NP_387969.1
|
| Others |
UniRef100:
UniRef100_P37573
UniRef90:
UniRef90_P37573
UniRef50:
UniRef50_P37573
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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