| Type | Description |
|---|---|
| Definition | tRNA methyltransferase 10A |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:05:00 | Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B. | 32392304 |
| 2020-07-18 11:39:00 | transcripts with increased m(6)A upon TRMT10A ablation contain an overrepresentation of m(1)G9-containing tRNAs codons read by tRNA(Gln(TTG)), tRNA(Arg(CCG)), and tRNA(Thr(CGT)) These findings collectively reveal the presence of coordinated mRNA and tRNA methylations and demonstrate a mechanism for regulating gene expression through the interactions between mRNA and tRNA modifying enzymes. | 32213595 |
| 2020-01-11 12:10:00 | demonstrate that human TRMT10A (hTRMT10A) and human TRMT10B (hTRMT10B) are not biochemically redundant | 31292261 |
| 2019-08-03 11:03:00 | tRNA guanosine 9 hypomethylation leads to tRNAGln fragmentation and that 5'-tRNAGln fragments mediate TRMT10A deficiency-induced beta-cell death. This study unmasks tRNA hypomethylation and fragmentation as a hitherto unknown mechanism of pancreatic beta-cell demise relevant to monogenic and polygenic forms of diabetes. | 30247717 |
| 2018-01-20 11:48:00 | A homozygous G to T transition in exon 2 of gene TRMT10A at nucleotide position 79 of the coding sequence was identified in a family with young-adult onset diabetes with intellectual disability, microcephaly and epilepsy. | 26526202 |
| Type | IDs |
|---|---|
| Synonymous | HEL-S-88, MSSGM, MSSGM1, RG9MTD2, TRM10 |
| Gene |
UniProtKB-ID:
TM10A_HUMAN,
V9HVY8_HUMAN
UniprotKB:
Q8TBZ6,
V9HVY8
UniParc:
UPI000006D359
EMBL:
AF106046,
AK313548,
CH471057,
BC028373,
EU668342
Ensembl:
ENSG00000145331
KO:
hsa:93587
|
| Nucleutide sequences |
EMBL-CDS:
BAG36324.1,
EAX06104.1,
AAD21019.1,
AAH28373.1,
EAX06105.1,
ACF94495.1
Gene_ORFName:
hCG_38740
Ensembl_TRS:
ENST00000394876,
ENST00000273962,
ENST00000394877
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378342,
ENSP00000378343,
ENSP00000273962
RefSeq:
NP_001362811.1,
NP_001128138.1,
NP_001362809.1,
NP_001362810.1,
NP_689505.1,
NP_001128137.1
|
| Others |
UniRef100:
UniRef100_Q8TBZ6
UniRef90:
UniRef90_Q8TBZ6
UniRef50:
UniRef50_Q8TBZ6
UniGene:
Hs.380412
CCDS:
CCDS3650.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员