| Type | Description |
|---|---|
| Definition | ubiquitination factor E4A |
| Date | Results | Publications |
|---|---|---|
| 2019-01-05 11:36:00 | UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the DDR and promotes enhancement and sustainment of K48- and K63-linked ubiquitin chains at these sites. This step is required for timely recruitment of the RAP80 and BRCA1 proteins and proper organization of RAP80- and BRCA1-associated protein complexes at DSB sites. | 29499138 |
| 2018-06-16 10:41:00 | UBE4A targets PCBP1 for proteasomal degradation and that UBE4A expression can serve as a novel biomarker in thyroid cancer patients. | 28963376 |
| 2017-09-02 10:16:00 | Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells | 27862841 |
| 2011-02-10 10:05:00 | Identified an intestinal cDNA clone encoding ubiquitination factor E4A (UBE4A), a U-box-type ubiquitin-protein ligase. The prevalence of anti-UBE4A IgG in patients with CD was significantly higher than that in patients with UC or healthy controls | 18069675 |
| 2011-02-10 10:01:00 | UBE4A was over-expressed in ovarian serous cystadenocarcinoma tissues, suggesting that the activity of ubiquitin-proteasome system is enhanced in ovarian cancer. | 17553343 |
| Type | IDs |
|---|---|
| Synonymous | E4, UBOX2, UFD2 |
| Gene |
UniProtKB-ID:
UBE4A_HUMAN
UniprotKB:
Q14139
UniParc:
UPI000013CD3F,
UPI00001FA485
EMBL:
EF445042,
CH471065,
BC112367,
D50916,
BC052643,
BC062695,
BC111417
Ensembl:
ENSG00000110344
KO:
hsa:9354
|
| Nucleutide sequences |
EMBL-CDS:
AAI12368.1,
EAW67371.1,
BAA09475.2,
AAH52643.1,
ACA06094.1,
AAH62695.1,
AAI11418.1
Ensembl_TRS:
ENST00000431736,
ENST00000252108
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387362,
ENSP00000252108
RefSeq:
NP_001191006.1,
NP_004779.2
|
| Others |
UniRef100:
UniRef100_Q14139
UniRef90:
UniRef90_Q14139
UniRef50:
UniRef50_Q14139
UniGene:
Hs.75275,
Hs.602967
CCDS:
CCDS8396.1,
CCDS55790.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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