| Type | Description |
|---|---|
| Definition | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
| Date | Results | Publications |
|---|---|---|
| 2016-07-16 11:25:00 | The role of TPTE2 in gallbladder cancer cells | 25676706 |
| 2013-05-24 12:42:00 | TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP and Dr-VSP, have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well. | 22896666 |
| 2012-11-24 10:14:00 | findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex | 22311048 |
| 2012-07-21 11:05:00 | the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells | 22164291 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | TPIP |
| Gene |
UniProtKB-ID:
TPTE2_HUMAN
UniprotKB:
Q6XPS3
UniParc:
UPI0002A0015E,
UPI000040738D,
UPI0000073010,
UPI0000407390,
UPI0001857DE6,
UPI00042DB65F,
UPI000013CEA5
EMBL:
BC128146,
AJ421033,
AJ421032,
CH471075,
AY219890,
AK301741,
BC128147,
AL590076,
FJ969729
Ensembl:
ENSG00000132958
KO:
hsa:93492
|
| Nucleutide sequences |
EMBL-CDS:
ACT21090.1,
CAD13144.1,
AAP45146.1,
EAX08219.1,
CAD13145.1,
AAI28147.1,
BAG63204.1,
AAI28148.1
Ensembl_TRS:
ENST00000400230,
ENST00000400103,
ENST00000390680,
ENST00000382978,
ENST00000255310
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000255310,
ENSP00000375098,
ENSP00000372438,
ENSP00000383089,
ENSP00000382974
RefSeq:
NP_001135440.1,
NP_570141.3,
NP_001258779.1,
NP_954863.2
|
| Others |
UniRef100:
UniRef100_Q6XPS3
UniRef90:
UniRef90_Q6XPS3
UniRef50:
UniRef50_Q6XPS3
UniGene:
Hs.377488
CCDS:
CCDS9285.1,
CCDS45013.1,
CCDS45014.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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