| Type | Description |
|---|---|
| Definition | TAO kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-07-28 10:03:00 | we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt | 28830982 |
| 2018-04-14 10:37:00 | A mutation in TAOK2 appears to cause a novel form of primary immunodeficiency, characterized by an impaired T cell proliferation upon activation. | 28385331 |
| 2013-08-10 11:51:00 | tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. | 23585562 |
| 2012-09-08 11:05:00 | TAOK2 is essential for dendrite morphogenesis; TAOK2 downregulation impairs basal dendrite formation without affecting apical dendrites. | 22683681 |
| 2010-01-21 00:00:00 | PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity | 12639963 |
| Type | IDs |
|---|---|
| Synonymous | MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2 |
| Gene |
UniProtKB-ID:
TAOK2_HUMAN
UniprotKB:
Q9UL54
UniParc:
UPI000013EDDA,
UPI000006FE55,
UPI0000073D88,
UPI0001917075
EMBL:
AK291473,
CH471238,
BC144344,
AF061943,
AB020688,
AC093512,
BC142663,
AL137701,
BC136655,
AY358942,
BC136653,
AF263313,
BC152413,
BC151221
Ensembl:
ENSG00000149930
KO:
hsa:9344
|
| Nucleutide sequences |
EMBL-CDS:
AAI36654.1,
AAI44345.1,
CAB70882.1,
AAQ89301.1,
BAF84162.1,
AAG38503.1,
AAD45616.1,
AAI36656.1,
EAW79964.1,
EAW79963.1,
AAI52414.1,
AAI51222.1,
BAA74904.2,
AAI42664.1
Gene_ORFName:
UNQ2971/PRO7431
Ensembl_TRS:
ENST00000308893,
ENST00000279394,
ENST00000416441,
ENST00000543033
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440336,
ENSP00000279394,
ENSP00000393048,
ENSP00000310094
RefSeq:
NP_004774.1,
XP_011544287.1,
XP_011544284.1,
XP_011544286.1,
NP_001238972.1,
XP_011544288.1,
XP_011544285.1,
NP_057235.2
|
| Others |
UniRef100:
UniRef100_Q9UL54
UniRef90:
UniRef90_Q9UL54
UniRef50:
UniRef50_Q9UL54
UniGene:
Hs.291623
CCDS:
CCDS58448.1,
CCDS10663.1,
CCDS10662.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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