| Type | Description |
|---|---|
| Definition | thyroid hormone receptor interactor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 12:32:00 | results expand the spectrum of TRIP4-associated disease to include mild adult forms, associate ASC-1 depletion with isolated primary muscle involvement, and establish TRIP4 as a causative gene for several congenital muscle diseases, including nemaline, core, centronuclear, and cytoplasmic-body myopathies. They also identify ASC-1 as a novel cell cycle regulator with a key role in cell proliferation. | 31794073 |
| 2020-02-29 11:38:00 | TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling. | 30905820 |
| 2019-03-30 10:15:00 | Study showed that TRIP4 promoted melanoma growth through modulation of COX-2 and iNOS expression partially by activating NF-kappaB signaling indirectly and partially by the direct anchoring of itself at COX-2 and iNOS promoter via synergy with p300. Clinical data showed that high expression of TRIP4 was positively correlated with increased expression of COX-2 and iNOS and predicted poor prognosis in melanoma patients. | 28899685 |
| 2016-12-17 11:32:00 | Reports reveal the first TRIP4 mutation defining a novel form of congenital muscle disease and establish the importance of ASC-1 in human skeletal muscle, identify transcriptional co-regulation as novel pathophysiological pathway, define ASC-1 as a regulator of late myogenic differentiation and suggest defects in myotube growth as a novel myopathic mechanism. | 27008887 |
| 2015-03-07 11:30:00 | GWAS in a large Spanish sample identifies TRIP4 (rs74615166) as a significant locus for Alzheimer's disease risk. | 24495969 |
| Type | IDs |
|---|---|
| Synonymous | ASC-1, ASC1, HsT17391, MDCDC, SMABF1, ZC2HC5 |
| Gene |
UniProtKB-ID:
TRIP4_HUMAN
UniprotKB:
Q15650
UniParc:
UPI0000035D96
EMBL:
CH471082,
BC012448,
AF168418,
AK314319,
L40371
Ensembl:
ENSG00000103671
KO:
hsa:9325
|
| Nucleutide sequences |
EMBL-CDS:
AAH12448.1,
BAG36967.1,
AAC41738.1,
AAF01278.1,
EAW77685.1
Ensembl_TRS:
ENST00000261884
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261884
RefSeq:
NP_001308853.1,
NP_057297.2
|
| Others |
UniRef100:
UniRef100_Q15650
UniRef90:
UniRef90_Q15650
UniRef50:
UniRef50_Q15650
UniGene:
Hs.500340
CCDS:
CCDS10194.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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