| Type | Description |
|---|---|
| Definition | ORAI calcium release-activated calcium modulator 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 11:08:00 | The differential expression of 55 genes involved in Ca(2+) signaling highlighted that only ORAI3 expression was significantly altered in smokers (regardless of COPD status). ORAI3 is involved in epithelial cell calcium signaling. ORAI3 is additionally involved in ciliary beating. | 30943377 |
| 2019-09-14 10:06:00 | Resistance was dependent on external calcium presence and thus Orai3 functionality. This effect allowed a downregulation of the p53 tumor suppressor protein expression via the pro-survival PI3K/Sgk-1/Sek-1 pathway. We demonstrated that p53 degradation occurred not only via Mdm2, but also via another unexpected E3 ubiquitin ligase, Nedd4-2. | 29323264 |
| 2019-06-15 12:28:00 | miR18a and miR18b positively regulate Orai3 whereas miR34a represses Orai3 expression and function. | 30216788 |
| 2018-12-01 10:20:00 | discovered that it was not the N termini, but the loop2 regions connecting TM2 and TM3 of Orai1 and Orai3 that featured distinct properties, which explained the different, isoform-specific behavior of Orai N-truncation mutants. | 29237733 |
| 2018-12-01 10:20:00 | the conserved portion of the Orai N terminus is essential for STIM1, as it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC channel activity. | 29237734 |
| Type | IDs |
|---|---|
| Synonymous | TMEM142C |
| Gene |
UniProtKB-ID:
ORAI3_HUMAN,
A0A024QZA7_HUMAN
UniprotKB:
Q9BRQ5,
A0A024QZA7
UniParc:
UPI00000735E7
EMBL:
BC022786,
BC015555,
CH471192,
BC006126
Ensembl:
ENSG00000175938
KO:
hsa:93129
|
| Nucleutide sequences |
EMBL-CDS:
AAH06126.2,
AAH15555.1,
AAH22786.1,
EAW52186.1,
EAW52185.1
Gene_ORFName:
hCG_21162
Ensembl_TRS:
ENST00000318663
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000322249
RefSeq:
NP_689501.1
|
| Others |
UniRef100:
UniRef100_Q9BRQ5
UniRef90:
UniRef90_Q9BRQ5
UniRef50:
UniRef50_Q9BRQ5
UniGene:
Hs.745104
CCDS:
CCDS10697.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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