| Type | Description |
|---|---|
| Definition | mitochondrial genome maintenance exonuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-03 11:03:00 | Besides the conserved two-cation-assisted catalytic mechanism, structural analysis of HsMGME1 and comparison with homologous proteins also clarified substrate binding and cleavage directionalities of the DNA double-strand break repair complexes RecBCD and AddAB. | 30247721 |
| 2018-12-29 10:16:00 | MGME1 is part of a termination complex acting at the end of the D-loop region where it modulates mtDNA replication and H-strand transcription termination | 29572490 |
| 2017-12-09 11:28:00 | A novel frameshift deletion in MGME1 causes early onset cerebellar ataxia. | 28711739 |
| 2017-06-10 11:15:00 | MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication. | 27220468 |
| 2015-10-31 10:05:00 | MGME1-mediated mtDNA processing is essential for faithful mitochondrial genome replication and might be required for intramolecular recombination of mtDNA. | 24986917 |
| Type | IDs |
|---|---|
| Synonymous | C20orf72, DDK1, MTDPS11, bA504H3.4 |
| Gene |
UniProtKB-ID:
MGME1_HUMAN,
Q5QPE7_HUMAN
UniprotKB:
Q9BQP7,
Q5QPE7
UniParc:
UPI00001285E8,
UPI000046FCD8
EMBL:
AL121585,
CH471133,
AK315532,
AK027503,
BC016869
Ensembl:
ENSG00000125871
KO:
hsa:92667
|
| Nucleutide sequences |
EMBL-CDS:
AAH16869.1,
EAX10260.1,
BAB55160.1,
EAX10261.1,
BAG37912.1
Ensembl_TRS:
ENST00000377710,
ENST00000377704
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000366939,
ENSP00000366933
RefSeq:
XP_005260927.1,
NP_001297267.1,
XP_006723726.1,
NP_001350667.1,
NP_443097.1,
NP_001297268.1,
XP_016883617.1,
XP_011527696.1,
XP_016883616.1,
XP_005260924.1,
XP_024307785.1
|
| Others |
UniRef100:
UniRef100_Q5QPE7,
UniRef100_Q9BQP7
UniRef90:
UniRef90_Q9BQP7,
UniRef90_Q5QPE7
UniRef50:
UniRef50_Q5QPE7,
UniRef50_Q9BQP7
UniGene:
Hs.320823
CCDS:
CCDS13131.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员