| Type | Description |
|---|---|
| Definition | NUMB like endocytic adaptor protein |
| Date | Results | Publications |
|---|---|---|
| 2018-04-07 11:29:00 | NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool | 27613838 |
| 2018-02-24 10:31:00 | let-7c inhibits Notch and progression markers but up-regulates Numbl in pancreatic cancer treated with quercetin | 27521217 |
| 2017-09-09 13:32:00 | investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation. | 28067668 |
| 2017-09-09 11:53:00 | These findings highlight the importance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis | 27383182 |
| 2015-10-17 11:18:00 | Numb/Numbl control VEGF receptor endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels. | 26069237 |
| Type | IDs |
|---|---|
| Synonymous | CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23 |
| Gene |
UniProtKB-ID:
NUMBL_HUMAN,
A8K033_HUMAN,
B7Z5W0_HUMAN,
A0A0C4DGH3_HUMAN
UniprotKB:
Q9Y6R0,
A8K033,
B7Z5W0,
A0A0C4DGH3
UniParc:
UPI000003032B,
UPI0000169DFF,
UPI0001914EEF,
UPI0000EE6D1C
EMBL:
AK299484,
BT009807,
AK289398,
AF015041,
BC001794,
AC010412,
CH471126
Ensembl:
ENSG00000105245
KO:
hsa:9253
|
| Nucleutide sequences |
EMBL-CDS:
AAD01549.1,
AAP88809.1,
EAW56986.1,
BAF82087.1,
BAH13046.1
Gene_ORFName:
hCG_20792
Ensembl_TRS:
ENST00000252891,
ENST00000540131,
ENST00000598779
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000252891,
ENSP00000472400,
ENSP00000442759
RefSeq:
NP_004747.1,
NP_001276908.1,
NP_001276909.1
|
| Others |
UniRef100:
UniRef100_Q9Y6R0,
UniRef100_A8K033
UniRef90:
UniRef90_Q9Y6R0
UniRef50:
UniRef50_Q9Y6R0
UniGene:
Hs.326953
CCDS:
CCDS12561.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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