| Type | Description |
|---|---|
| Definition | ribosomal protein S6 kinase A5 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:54:00 | MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjogren's Syndrome by Targeting Mitogen- and Stress-Activated | 31281310 |
| 2019-12-14 12:14:00 | show that expression of nuclear activates ERK and MSK1, that ERK activation is required for MSK1 activation, and that both ERK and MSK1 activation are required for apoptosis | 30679314 |
| 2019-06-01 10:12:00 | These studies suggest that MSK1 acts through a direct interaction with p53 to function as a transcriptional coactivator and that MSK1 activation by upstream MAPK signaling is important for efficient p21 gene expression. | 30305627 |
| 2019-04-13 11:24:00 | We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for luminal cell differentiation, including the GATA3 and FOXA1 transcription factors, by modulating their promoter chromatin status. | 29358704 |
| 2018-04-21 12:02:00 | MSK1 was overexpressed in 148 out of 329 colorectal cancer (CRC) patients. CRC patients with high MSK1 expression had shorter overall survival than those with low MSK1, especially among patients with stage III tumors. Overexpression of MSK1 is associated with poor prognosis in CRC and is connected to tumor aggressiveness. | 28314603 |
| Type | IDs |
|---|---|
| Synonymous | MSK1, MSPK1, RLPK |
| Gene |
UniProtKB-ID:
KS6A5_HUMAN
UniprotKB:
O75582
UniParc:
UPI0000071283,
UPI0000031C30,
UPI0001914C86
EMBL:
BC017187,
AL133454,
AK295266,
AF090421,
AF080000,
AL159191,
AF074393,
AL121784
Ensembl:
ENSG00000100784
KO:
hsa:9252
|
| Nucleutide sequences |
EMBL-CDS:
BAH12021.1,
AAC31171.1,
AAC69577.1,
AAD23915.1,
AAH17187.1
Ensembl_TRS:
ENST00000536315,
ENST00000418736,
ENST00000614987
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000442803,
ENSP00000402787,
ENSP00000479667
RefSeq:
NP_001309157.1,
NP_001309164.1,
NP_001309163.1,
NP_001309159.1,
NP_001309167.1,
NP_001309161.1,
NP_001309158.1,
NP_001309162.1,
NP_004746.2,
NP_001309166.1,
NP_001309160.1,
NP_872198.1,
NP_001309156.1,
NP_001309165.1,
XP_016877275.1
|
| Others |
UniRef100:
UniRef100_O75582
UniRef90:
UniRef90_O75582
UniRef50:
UniRef50_O75582
UniGene:
Hs.510225
CCDS:
CCDS9893.1,
CCDS45149.1,
CCDS81839.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员