| Type | Description |
|---|---|
| Definition | charged multivesicular body protein 4C |
| Date | Results | Publications |
|---|---|---|
| 2019-08-10 11:33:00 | The role of CHMP4C in the formation of stable kinetochore-microtubule attachments during the cell cycle is reported. | 29562220 |
| 2019-07-06 10:51:00 | Chmp4c regulates kinetochore-microtubule interactions to promote accurate chromosome segregation.Chmp4c promotes Hec1 and Nuf2 kinetochore localization.Chmp4c binds and bundles microtubules. | 29968190 |
| 2019-02-23 12:58:00 | These results show that Chmp4c regulates the mitotic spindle checkpoint by promoting localization of the RZZ complex to unattached kinetochores. | 29362225 |
| 2018-10-13 12:01:00 | Data demonstrate the biological importance of the abscission checkpoint and suggest that dysregulation of abscission by CHMP4CT232 may synergize with oncogene-induced mitotic stress to promote genomic instability and tumorigenesis. | 30181294 |
| 2017-12-16 12:18:00 | Results show that CHMP4C, under the regulation of the chromosomal passenger complex, binds to highly curved membranes and promotes the closure of membrane gaps. Two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesisI but the phosphorylation is not required for its assembly into spiral filaments. Also, the centralspindlin complex associates preferentially with the with unphosphorylated form. | 27784789 |
| Type | IDs |
|---|---|
| Synonymous | SNF7-3, Shax3, VPS32C |
| Gene |
UniProtKB-ID:
CHM4C_HUMAN
UniprotKB:
Q96CF2
UniParc:
UPI000005032A
EMBL:
AK314873,
BC014321,
CH471068,
AY329086,
AB120734
Ensembl:
ENSG00000164695
KO:
hsa:92421
|
| Nucleutide sequences |
EMBL-CDS:
BAG37388.1,
AAH14321.1,
EAW87107.1,
AAQ91195.1,
BAC87888.1
Ensembl_TRS:
ENST00000297265
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000297265
RefSeq:
NP_689497.1
|
| Others |
UniRef100:
UniRef100_Q96CF2
UniRef90:
UniRef90_Q96CF2
UniRef50:
UniRef50_Q96CF2
UniGene:
Hs.183861
CCDS:
CCDS6233.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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