| Type | Description |
|---|---|
| Definition | STE20 related adaptor alpha |
| Date | Results | Publications |
|---|---|---|
| 2017-10-28 11:12:00 | We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder. | 27170158 |
| 2010-05-31 11:24:00 | aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis | 20424326 |
| 2010-01-26 11:12:00 | Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 and the activation of the LKB1-dependent AMPK pathway were discovered. | 17921699 |
| 2010-01-25 11:28:00 | study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function | 19892943 |
| 2010-01-21 00:00:00 | ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. | 19513107 |
| Type | IDs |
|---|---|
| Synonymous | LYK5, NY-BR-96, PMSE, STRAD, STRAD alpha, Stlk |
| Gene |
UniProtKB-ID:
STRAA_HUMAN,
Q86YC8_HUMAN,
J3QS66_HUMAN,
J3QQS3_HUMAN,
A0A1W2PQF1_HUMAN,
A0A1W2PS04_HUMAN
UniprotKB:
Q7RTN6,
Q86YC8,
J3QS66,
J3QQS3,
A0A1W2PQF1,
A0A1W2PS04
UniParc:
UPI000019C3DA,
UPI000013CBBE,
UPI0005D036DB,
UPI000006F308,
UPI0003E68ADF,
UPI00003D185B,
UPI0001B83813,
UPI00017A6CAB,
UPI000000DA72,
UPI000387D5C7,
UPI000387B669
EMBL:
AY290821,
AC015651,
BK001542,
BC043641,
AK074771,
AF308302,
AK293160,
CH471109,
AK075005,
AC046185,
AL832407,
AK301331
Ensembl:
ENSG00000266173
KO:
hsa:92335
|
| Nucleutide sequences |
EMBL-CDS:
BAC11349.1,
AAP42280.1,
BAC11197.1,
BAG62879.1,
AAG48269.1,
CAI46194.1,
DAA01797.1,
BAG56704.1,
EAW94283.1,
AAH43641.1
Ensembl_TRS:
ENST00000336174,
ENST00000392950,
ENST00000640999,
ENST00000447001,
ENST00000375840,
ENST00000582137,
ENST00000639835,
ENST00000638702,
ENST00000617949,
ENST00000245865,
ENST00000578008,
ENST00000578801,
ENST00000638193,
ENST00000638309
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000491643,
ENSP00000376677,
ENSP00000398841,
ENSP00000365000,
ENSP00000492578,
ENSP00000462922,
ENSP00000491017,
ENSP00000336655,
ENSP00000481505,
ENSP00000245865,
ENSP00000464547,
ENSP00000463872,
ENSP00000491928,
ENSP00000492877
RefSeq:
NP_001003787.1,
NP_001350715.1,
XP_005257860.1,
NP_001350718.1,
NP_001350716.1,
XP_005257858.1,
NP_001003786.1,
XP_011523768.1,
NP_001350719.1,
NP_001350720.1,
XP_005257856.1,
NP_699166.2,
NP_001159441.1,
XP_016880803.1,
XP_011523769.1,
NP_001159442.1,
NP_001003788.1,
NP_001350717.1
|
| Others |
UniRef100:
UniRef100_Q7RTN6,
UniRef100_A0A1W2PQF1,
UniRef100_A0A1W2PS04,
UniRef100_Q86YC8,
UniRef100_J3QQS3,
UniRef100_J3QS66
UniRef90:
UniRef90_Q7RTN6-6,
UniRef90_A0A2I3LS24,
UniRef90_A0A287B232,
UniRef90_A0A340XC92,
UniRef90_Q7RTN6
UniRef50:
UniRef50_A0A2I3LS24,
UniRef50_Q7RTN6,
UniRef50_A0A2K6F7A9,
UniRef50_Q7RTN6-6,
UniRef50_A0A287B232
UniGene:
Hs.514402
CCDS:
CCDS86632.1,
CCDS42367.1,
CCDS58585.1,
CCDS11642.1,
CCDS32703.1,
CCDS54156.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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