PF3D7_0417200 - bifunctional dihydrofolate reductase-thymidylate synthase-BMKCloudï½ç¾è¿å®¢äº

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9221804 PF3D7_0417200

基因描述

Type	Description
Definition	bifunctional dihydrofolate reductase-thymidylate synthase

研究结论

Date	Results	Publications
2018-03-31 10:04:00	Polymorphism in dihydrofolate reductase and dihydropteroate synthetase genes after five years of artemisinin combination therapy (ACT) implementation in urban India has been reported.	28533179
2015-04-18 11:18:00	Plasmodium vivax and P. falciparum dhfr and dhps genes were sequenced to detect nucleotide polymorphisms in malaria patients before introduction of chloroquine and sulphadoxine-pyrimethamine.	25311473
2014-08-23 11:50:00	Report on the mutational analysis of pfdhfr and pfdhps in single Plasmodium falciparum infection isolates from the interior division of Sabah, Malaysian Borneo.	24321120
2013-09-14 11:42:00	This study demonstrated the interactions between the pfDHFR and pfTS domains of the bifunctional pfDHFR-TS, and revealed that the junctional region linking the two protein domains is essential for the expression of catalytically active pfTS domain.	23497065
2011-05-28 11:19:00	the TS subunit interface between Plasmodium species is sufficiently conserved to allow formation of fully active cross-species heterodimer	20577818

名称对应

Type	IDs
Synonymous	PFD0830w
Gene	UniProtKB-ID: Q8I1R6_PLAF7 UniprotKB: Q8I1R6 UniParc: UPI0000086421 EMBL: AL844503 EnsemblGenome: PF3D7_0417200 KO: pfa:PF3D7_0417200
Nucleutide sequences	EMBL-CDS: CAD49208.1 Gene_ORFName: PF3D7_0417200
Protein sequencees	RefSeq: XP_001351479.1
Others	UniRef100: UniRef100_W7K8T7 UniRef90: UniRef90_P13922 UniRef50: UniRef50_P13922

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28533179	Polymorphisms in pfdhfr and pfdhps genes after five years of artemisinin combination therapy (ACT) implementation from urban Kolkata, India. Infect Genet Evol Moytrey Chatterjee , Swagata Ganguly , Pabitra Saha , Subhasish K Guha , Ardhendu Kumar Maji	2017-09-01	-
25447287	Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins. Mol. Biochem. Parasitol. Chayaphat Wongsombat , Aiyada Aroonsri , Sumalee Kamchonwongpaisan , Hugh P Morgan , Malcolm D Walkinshaw , Yongyuth Yuthavong , Philip J Shaw	2014-11-01	-
25311473	Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy. Malar J Karryn J Gresty , Karen-Ann Gray , Albino Bobogare , Lyndes Wini , George Taleo , Jeffrey Hii , Qin Cheng , Norman C Waters	2014-10-14	-
24321120	Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia. Malar. J. Tiek Ying Lau , Mersumpin Sylvi , Timothy William	2013-01-01	DHPS, DHFR-TS
23497065	Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Malar. J. Natpasit Chaianantakul , Rachada Sirawaraporn , Worachart Sirawaraporn	2013-01-01	DHFR-TS
20577818	Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax. Mol. Biol. Rep. Manee Chanama , Suchart Chanama , Philip J Shaw , Penchit Chitnumsub , Ubolsree Leartsakulpanich , Yongyuth Yuthavong	2011-02-01	-
12704428	Insights into antifolate resistance from malarial DHFR-TS structures. Nat. Struct. Biol. Jirundon Yuvaniyama , Penchit Chitnumsub , Sumalee Kamchonwongpaisan , Jarunee Vanichtanankul , Worachart Sirawaraporn , Paul Taylor , Malcolm D Walkinshaw , Yongyuth Yuthavong	2003-05-01	-
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature N Hall , A Pain , M Berriman , C Churcher , B Harris , D Harris , K Mungall , S Bowman , R Atkin , S Baker , A Barron , K Brooks , C O Buckee , C Burrows , I Cherevach , C Chillingworth , T Chillingworth , Z Christodoulou , L Clark , R Clark , C Corton , A Cronin , R Davies , P Davis , P Dear , F Dearden , J Doggett , T Feltwell , A Goble , I Goodhead , R Gwilliam , N Hamlin , Z Hance , D Harper , H Hauser , T Hornsby , S Holroyd , P Horrocks , S Humphray , K Jagels , K D James , D Johnson , A Kerhornou , A Knights , B Konfortov , S Kyes , N Larke , D Lawson , N Lennard , A Line , M Maddison , J McLean , P Mooney , S Moule , L Murphy , K Oliver , D Ormond , C Price , M A Quail , E Rabbinowitsch , M-A Rajandream , S Rutter , K M Rutherford , M Sanders , M Simmonds , K Seeger , S Sharp , R Smith , R Squares , S Squares , K Stevens , K Taylor , A Tivey , L Unwin , S Whitehead , J Woodward , J E Sulston , A Craig , C Newbold , B G Barrell	2002-10-03	MAL7P1.110, MAL7P1.113, MAL7P1.104, MAL7P1.93, MAL7P1.94, PF07_0005, PF07_0014, MAL7P1.162, MAL7P1.164, MAL7P1.4, MAL7P1.69, MAL7P1.73, MAL7P1.147, MAL7P1.150, MAL7P1.151, MAL7P1.161, MAL7P1.75, MAL7P1.81, MAL7P1.86, PF07_0021, PF07_0023, PF07_0027, PF07_0040, MAL7P1.137, MAL7P1.139, MAL7P1.145, PF07_0046, PF07_0047, PF07_0054, PF07_0057, PF07_0059, PF07_0062, PF07_0065, PF07_0070, PF07_0071, PfCDPK4, PF07_0073, PF07_0079, PF07_0080, PF07_0085, PF07_0086, PF07_0088, PF07_0091, PF07_0098, MAL7P1.130, PF07_0103, PF07_0105, PF07_0112, PF07_0115, PF07_0117, PF07_0123, MAL7P1.118, MAL7P1.12, MAL7P1.122, MAL7P1.20, PfCRT, MAL7P1.37, MAL7P1.38, MAL8P1.13, MAL8P1.131, MAL8P1.23, MAL8P1.12, MAL8P1.125, MAL8P1.128, MAL8P1.110, PF08_0055, PF08_0056, PF08_0059, PF08_0069, FeSOD, PF08_0075, PF08_0076, PF08_0084, PF08_0085, PF08_0096, PF08_0108, PF08_0126, PF08_0129, PF08_0132, PF08_0136b, MAL8P1.48, MAL8P1.51, MAL8P1.37, MAL8P1.40, MAL8P1.43, MAL8P1.108, MAL8P1.140, MAL8P1.3, MAL8P1.31, MAL8P1.32, MAL8P1.33, MAL8P1.76, MAL8P1.78, MAL8P1.83, MAL8P1.9, PF08_0006, PF08_0009, PF08_0011, PF08_0014

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