| Type | Description |
|---|---|
| Definition | bone morphogenetic protein 15 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 10:52:00 | It was observed a statistically significant difference in genotype distribution of BMP15:c.852C>T between group POI and controls (p < 0.001). TT and TC genotypes were more frequently observed in group POI.. Concerning GDF9, no association was found among the studied genetic variants and POI or high FSH groups | 31392662 |
| 2019-04-20 11:36:00 | We observed no significant difference associated with POI in the patients when compared with a healthy control group (p > 0.05). Also, no exonic variants were found for the genes BMP15 and FOXL2 in the individuals tested | 29916099 |
| 2019-03-09 12:44:00 | GDF9 + BMP15, but not separately, significantly induce AMH expression in vitro and in vivo. GDF9 + BMP15, through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of H3K27ac, facilitating AMH expression. | 30060157 |
| 2018-12-22 11:35:00 | The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women. | 30039232 |
| 2018-11-10 10:04:00 | Data suggest that GDF9 and BMP15 are oocyte-secreted factors with leading roles in control of ovarian function in female reproduction, modulating both fate of somatic granulosa cells and quality/developmental competence of the egg. (GDF9 = growth and differentiation factor-9; BMP15 = bone morphogenetic protein-15) [REVIEW] | 29544636 |
| Type | IDs |
|---|---|
| Synonymous | GDF9B, ODG2, POF4 |
| Gene |
UniProtKB-ID:
BMP15_HUMAN
UniprotKB:
O95972
UniParc:
UPI000013CD7C
EMBL:
AJ132405,
BC069155,
AF082350,
BC117266,
BC117264,
AL359914,
AF082349
Ensembl:
ENSG00000130385
KO:
hsa:9210
|
| Nucleutide sequences |
EMBL-CDS:
AAI17267.1,
AAI17265.1,
CAB43531.1,
AAH69155.1,
AAC99768.1
Ensembl_TRS:
ENST00000252677
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000252677
RefSeq:
NP_005439.2
|
| Others |
UniRef100:
UniRef100_O95972
UniRef90:
UniRef90_O95972
UniRef50:
UniRef50_O95972
UniGene:
Hs.532692
CCDS:
CCDS14334.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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