| Type | Description |
|---|---|
| Definition | Rho/Rac guanine nucleotide exchange factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 10:24:00 | GEF-H1 is further regulated by Src phosphorylation, activating GEF-H1 in a narrower band ~0-2 microm from the cell edge, in coordination with cell protrusions. This indicates a synergistic intersection between MT dynamics and Src signaling in RhoA activation through GEF-H1. | 31420453 |
| 2019-08-31 12:46:00 | the present study revealed that GEF-H1 is upregulated in colon cancer tissues and plays a key role in colon cancer metastasis | 30846413 |
| 2019-05-11 11:00:00 | role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control | 30305100 |
| 2018-06-16 11:39:00 | Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. | 29089450 |
| 2017-08-05 10:32:00 | depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly. | 28096473 |
| Type | IDs |
|---|---|
| Synonymous | GEF, GEF-H1, GEFH1, LFP40, NEDMHM, P40 |
| Gene |
UniProtKB-ID:
ARHG2_HUMAN,
A0A5F9ZI21_HUMAN
UniprotKB:
Q92974,
A0A5F9ZI21
UniParc:
UPI0000072FDD,
UPI000045892C,
UPI000006E310,
UPI0007DC6BF2
EMBL:
BT007407,
AB014551,
CH471121,
AL355388,
AF486838,
X15610,
BC020567,
AL512715,
KF455040,
U72206
Ensembl:
ENSG00000116584
KO:
hsa:9181
|
| Nucleutide sequences |
EMBL-CDS:
AAC97383.1,
AAH20567.1,
CAC21656.1,
CAA33634.1,
AAL96658.1,
EAW53014.1,
BAA31626.3,
EAW53013.1,
AAP36075.1,
EAW53015.1
Ensembl_TRS:
ENST00000313695,
ENST00000361247,
ENST00000313667,
ENST00000673475
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000315325,
ENSP00000314787,
ENSP00000354837,
ENSP00000500802
RefSeq:
NP_001155855.1,
XP_011508441.1,
XP_011508445.1,
NP_001337040.1,
XP_006711687.1,
NP_004714.2,
XP_005245647.1,
NP_001155856.1,
XP_016858283.1,
NP_001337041.1,
XP_011508438.2,
XP_005245651.1,
XP_005245645.1,
XP_006711685.1,
XP_016858287.1,
XP_005245648.1,
XP_016858284.1,
XP_006711686.1,
XP_005245646.1,
XP_006711689.1,
XP_005245644.1,
XP_024306591.1,
NP_001337039.1,
XP_011508439.2,
XP_016858286.1,
XP_024306583.1,
XP_006711688.1
|
| Others |
UniRef100:
UniRef100_A0A5F9ZI21,
UniRef100_Q92974
UniRef90:
UniRef90_Q92974
UniRef50:
UniRef50_Q92974
UniGene:
Hs.743352
CCDS:
CCDS53376.1,
CCDS1125.1,
CCDS53375.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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