| Type | Description |
|---|---|
| Definition | myosin light chain kinase 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-03 11:47:00 | Study identified MYLK3 mutations associated with familial dilated cardiomyopathy. In vitro experiments and immunohistochemistry suggested that the MYLK3 mutations identified in this study result in markedly reduced levels of protein expression and myosin light chain 2 phosphorylation. | 29235529 |
| 2014-07-19 11:43:00 | This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism. | 24722904 |
| 2014-04-12 11:21:00 | Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase. | 23863751 |
| 2013-12-14 11:53:00 | These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway. | 23591626 |
| 2010-01-21 00:00:00 | Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v. | 17885681 |
| Type | IDs |
|---|---|
| Synonymous | MLCK, MLCK2, caMLCK |
| Gene |
UniProtKB-ID:
MYLK3_HUMAN
UniprotKB:
Q32MK0
UniParc:
UPI0001914EBF,
UPI000059D380
EMBL:
AK299443,
BC109097,
AC007225,
AB451455,
AJ247087
Ensembl:
ENSG00000140795
KO:
hsa:91807
|
| Nucleutide sequences |
EMBL-CDS:
BAG70269.1,
BAH13034.1,
AAI09098.2,
CAC42766.1
Ensembl_TRS:
ENST00000394809,
ENST00000536476
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000439297,
ENSP00000378288
RefSeq:
XP_006721397.1,
NP_872299.2,
NP_001295230.1
|
| Others |
UniRef100:
UniRef100_Q32MK0
UniRef90:
UniRef90_Q32MK0
UniRef50:
UniRef50_Q3UIZ8
UniGene:
Hs.130465
CCDS:
CCDS76861.1,
CCDS10723.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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