| Type | Description |
|---|---|
| Definition | alkB homolog 8, tRNA methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:53:00 | Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming(). | 31765888 |
| 2020-03-14 12:34:00 | Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification. | 31079898 |
| 2017-06-03 12:11:00 | findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer | 27329810 |
| 2013-09-06 09:40:00 | Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. | 21285950 |
| 2013-09-06 09:37:00 | The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. | 20123966 |
| Type | IDs |
|---|---|
| Synonymous | ABH8, TRM9, TRMT9, TRMT9A |
| Gene |
UniProtKB-ID:
ALKB8_HUMAN
UniprotKB:
Q96BT7
UniParc:
UPI0000EE3A38,
UPI0000072C37,
UPI00001FA2E7,
UPI00017A6D55
EMBL:
CH471065,
AK304413,
AK095523,
AK293603,
AB218768,
BC015183,
AP001823
Ensembl:
ENSG00000137760
KO:
hsa:91801
|
| Nucleutide sequences |
EMBL-CDS:
AAH15183.1,
BAG65244.1,
BAC04566.1,
BAG57067.1,
EAW67089.1,
BAG16270.1,
EAW67090.1
Ensembl_TRS:
ENST00000389568,
ENST00000417449,
ENST00000429370,
ENST00000260318,
ENST00000428149
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000374219,
ENSP00000391225,
ENSP00000260318,
ENSP00000397673,
ENSP00000415885
RefSeq:
XP_016874042.1,
NP_620130.2,
NP_001365062.1,
XP_005271786.1,
XP_016874046.1,
NP_001287939.2,
XP_005271785.1
|
| Others |
UniRef100:
UniRef100_Q96BT7
UniRef90:
UniRef90_Q96BT7
UniRef50:
UniRef50_Q96BT7
UniGene:
Hs.503763
CCDS:
CCDS8337.2,
CCDS73376.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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