MAP3K13 - mitogen-activated protein kinase kinase kinase 13-BMKCloudï½ç¾è¿å®¢äº

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9175 MAP3K13

基因描述

Type	Description
Definition	mitogen-activated protein kinase kinase kinase 13

研究结论

Date	Results	Publications
2017-12-02 10:39:00	Data indicate that miR-206's effect on Myc was mediated through MAP3K13.	26918941
2017-08-05 10:10:00	LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury.	28641113
2010-06-30 22:06:00	Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)	20379614
2010-01-21 00:00:00	Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.	12186766

名称对应

Type	IDs
Synonymous	LZK, MEKK13, MLK
Gene	UniProtKB-ID: M3K13_HUMAN UniprotKB: O43283 UniParc: UPI000192C296, UPI000192C298, UPI0000E57443, UPI000006CF91, UPI000192C297 EMBL: AK296961, AC099661, BC031677, BC111726, CH471052, AK297646, AB001872, AC132516, AK312714, Z25428, AC128680, AK302951 Ensembl: ENSG00000073803 KO: hsa:9175
Nucleutide sequences	EMBL-CDS: BAG35589.1, BAA24817.1, AAH31677.1, BAG64106.1, EAW78225.1, AAI11727.1, CAA80915.1, BAG60014.1, BAG59505.1, EAW78224.1 Ensembl_TRS: ENST00000443863, ENST00000438053, ENST00000265026, ENST00000424227, ENST00000446828, ENST00000433092
Protein sequencees	Ensembl_PRO: ENSP00000403561, ENSP00000409325, ENSP00000399910, ENSP00000265026, ENSP00000389798, ENSP00000411483 RefSeq: XP_016862948.1, XP_011511612.1, NP_001229243.1, XP_016862945.1, NP_004712.1, XP_016862946.1, XP_016862947.1, NP_001229246.1
Others	UniRef100: UniRef100_O43283 UniRef90: UniRef90_O43283 UniRef50: UniRef50_O43283 UniGene: Hs.591306, Hs.634586 CCDS: CCDS3270.1, CCDS56298.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31186535	The MAP3K13-TRIM25-FBXW7Î± axis affects c-Myc protein stability and tumor development. Cell Death Differ Qiang Zhang , Xu Li , Kasa Cui , Cheng Liu , Mingzhi Wu , Edward V Prochownik , Youjun Li	2020-02-01	-
28641113	Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron Derek S Welsbie , Katherine L Mitchell , Vinod Jaskula-Ranga , Valentin M Sluch , Zhiyong Yang , Jessica Kim , Eugen Buehler , Amit Patel , Scott E Martin , Ping-Wu Zhang , Yan Ge , Yukan Duan , John Fuller , Byung-Jin Kim , Eman Hamed , Xitiz Chamling , Lei Lei , Iain D C Fraser , Ze'ev A Ronai , Cynthia A Berlinicke , Donald J Zack	2017-06-21	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
26918941	microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13. Oncotarget Han Han , Yuxing Chen , Li Cheng , Edward V Prochownik , Youjun Li	2016-03-29	-
22837378	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am. J. Respir. Crit. Care Med. Jemma B Wilk , Nick R G Shrine , Laura R Loehr , Jing Hua Zhao , Ani Manichaikul , Lorna M Lopez , Albert Vernon Smith , Susan R Heckbert , Joanna Smolonska , Wenbo Tang , Daan W Loth , Ivan Curjuric , Jennie Hui , Michael H Cho , Jeanne C Latourelle , Amanda P Henry , Melinda Aldrich , Per Bakke , Terri H Beaty , Amy R Bentley , Ingrid B Borecki , Guy G Brusselle , Kristin M Burkart , Ting-hsu Chen , David Couper , James D Crapo , Gail Davies , JosÃ©e Dupuis , Nora Franceschini , Amund Gulsvik , Dana B Hancock , Tamara B Harris , Albert Hofman , Medea Imboden , Alan L James , Kay-Tee Khaw , Lies Lahousse , Lenore J Launer , Augusto Litonjua , Yongmei Liu , Kurt K Lohman , David A Lomas , Thomas Lumley , Kristin D Marciante , Wendy L McArdle , Bernd Meibohm , Alanna C Morrison , Arthur W Musk , Richard H Myers , Kari E North , Dirkje S Postma , Bruce M Psaty , Stephen S Rich , Fernando Rivadeneira , Thierry Rochat , Jerome I Rotter , MarÃa Soler Artigas , John M Starr , AndrÃ© G Uitterlinden , Nicholas J Wareham , Cisca Wijmenga , Pieter Zanen , Michael A Province , Edwin K Silverman , Ian J Deary , Lyle J Palmer , Patricia A Cassano , Vilmundur Gudnason , R Graham Barr , Ruth J F Loos , David P Strachan , Stephanie J London , H Marike Boezen , Nicole Probst-Hensch , Sina A Gharib , Ian P Hall , George T O'Connor , Martin D Tobin , Bruno H Stricker	2012-10-01	-
22623531	Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc. Natl. Acad. Sci. U.S.A. Masafumi Toyoshima , Heather L Howie , Maki Imakura , Ryan M Walsh , James E Annis , Aaron N Chang , Jason Frazier , B Nelson Chau , Andrey Loboda , Peter S Linsley , Michele A Cleary , Julie R Park , Carla Grandori	2012-06-12	CDH5, NR1H3, CDK2, TRIB1, SPEG, ARFGEF2, SLC25A26, C17orf49, CPS1, MYO3B, CSNK1E, CTPS1, CTSD, GRK3, DDB2, EFNA5, ALDOA, SNRNP200, BRD4, PES1, FBXO5, GLI1, CECR2, GNRHR, GTF2H4, SH3KBP1, HCK, CXXC1, HPS1, HSD17B4, ICT1, IGF2R, FAM131C, ITGB5, LIMK2, MATK, MCL1, MYC, MYCN, MYLK, NEK2, NQO2, NTRK1, WEE2, PCBD1, ATP5D, REV1, PDK1, CDK12, PI4KB, POLA1, POLH, POLR2E, POLR2I, HAUS7, PKN1, PBK, SULF2, MAP2K3, MAP2K7, PAK6, PSMC2, CAMK1G, SCYL1, PTPN9, RAD21, RASGRF1, GRK1, SDC4, NECAB3, SLC1A4, WNK1, BMPR1A, BNIP2, BOK, SULT1A2, SUV39H1, BTK, TIE1, TXK, UBE2I, WEE1, YES1, CENPO, HECTD3, NEIL1, ALPK1, RASSF7, PTP4A2, CAMK2D, CAMK2G, KIF18A, TRRAP, GSG2, AIFM2, IRS2, CRADD, CCNK, PRC1
21988832	Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. Jian Wang , Keke Huo , Lixin Ma , Liujun Tang , Dong Li , Xiaobi Huang , Yanzhi Yuan , Chunhua Li , Wei Wang , Wei Guan , Hui Chen , Chaozhi Jin , Juncheng Wei , Wanqiao Zhang , Yongsheng Yang , Qiongming Liu , Ying Zhou , Cuili Zhang , Zhihao Wu , Wangxiang Xu , Ying Zhang , Tao Liu , Donghui Yu , Yaping Zhang , Liang Chen , Dewu Zhu , Xing Zhong , Lixin Kang , Xiang Gan , Xiaolan Yu , Qi Ma , Jing Yan , Li Zhou , Zhongyang Liu , Yunping Zhu , Tao Zhou , Fuchu He , Xiaoming Yang	2011-10-11	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20379614	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol. Med. Jed E Rose , FrÃ©dÃ©rique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl	2010-03-17	-
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7

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