| Type | Description |
|---|---|
| Definition | proprotein convertase subtilisin/kexin type 7 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:36:00 | Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis. | 33565643 |
| 2020-10-24 14:09:00 | The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity. | 31915245 |
| 2020-07-18 11:18:00 | PCSK7 gene variation is associated with dyslipidemia and more severe liver disease in high risk individuals, likely by modulating PCSK7 expression/activity. | 30918065 |
| 2017-04-08 11:58:00 | Our present data suggest that PCSK7 as well as PCSK9 may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes. | 26763881 |
| 2017-03-25 10:57:00 | PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis. | 26868056 |
| Type | IDs |
|---|---|
| Synonymous | LPC, PC7, PC8, SPC7 |
| Gene |
UniProtKB-ID:
PCSK7_HUMAN
UniprotKB:
Q16549
UniParc:
UPI0000070E4E
EMBL:
BC010696,
U40623,
AB231710,
AK312429,
AK222907,
BT006870,
U33849,
AF057710,
CH471065,
EF445005
Ensembl:
ENSG00000160613
KO:
hsa:9159
|
| Nucleutide sequences |
EMBL-CDS:
ACA06036.1,
ACA06037.1,
AAD55137.1,
AAH10696.1,
BAD96627.1,
BAG35338.1,
EAW67305.1,
AAP35516.1,
AAB03087.1,
AAC50417.1,
BAE46876.1
Ensembl_TRS:
ENST00000320934
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000325917
RefSeq:
XP_006719003.1,
XP_024304533.1,
XP_024304532.1,
NP_004707.2
|
| Others |
UniRef100:
UniRef100_Q16549
UniRef90:
UniRef90_Q16549
UniRef50:
UniRef50_Q16549
UniGene:
Hs.648612
CCDS:
CCDS8382.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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