| Type | Description |
|---|---|
| Definition | protein kinase domain containing, cytoplasmic |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:18:00 | Taken together, these results suggest that Vlk may function as a signaling regulator in extracellular space to modulate the Hedgehog pathway | 31845979 |
| 2020-07-04 10:42:00 | Each patient had a homozygous gene disrupting variant in PKDCC considered to explain the skeletal phenotypes shared by both. | 30478137 |
| 2017-08-12 11:45:00 | VLK secretion can be regulated by external cues, intracellular signal proteins, and mechanical stretch, and VLK can in turn regulate TyrP of ECM proteins secreted by trabecular meshwork cells and control cell shape, actin stress fibers, and focal adhesions. | 27591737 |
| 2015-12-12 12:02:00 | The Fam20C-and VLK-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease | 25862977 |
| 2015-01-31 11:37:00 | VLK is rapidly and quantitatively secreted from platelets in response to stimuli and can tyrosine phosphorylate coreleased proteins utilizing endogenous as well as exogenous ATP sources. | 25171405 |
| Type | IDs |
|---|---|
| Synonymous | SGK493, Vlk |
| Gene |
UniProtKB-ID:
PKDCC_HUMAN
UniprotKB:
Q504Y2
UniParc:
UPI0000EE25C6
EMBL:
BC007901,
BC094697,
BC062988,
BC110514,
BC110513,
AC013480,
CH471053
Ensembl:
ENSG00000162878
KO:
hsa:91461
|
| Nucleutide sequences |
EMBL-CDS:
EAX00325.1,
EAX00326.1,
AAI10514.1,
AAH62988.1,
AAI10515.1,
AAH94697.1,
AAH07901.2
Ensembl_TRS:
ENST00000294964
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000294964
RefSeq:
NP_612379.2
|
| Others |
UniRef100:
UniRef100_Q504Y2
UniRef90:
UniRef90_Q504Y2
UniRef50:
UniRef50_Q5RJI4
UniGene:
Hs.408542
CCDS:
CCDS33186.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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