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91445 RNF185

91445

RNF185

ring finger protein 185

protein-coding

Homo sapiens

基因描述

Type Description
Definition ring finger protein 185

研究结论

Date Results Publications
2018-07-14 11:43:00 increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression. 29481911
2017-08-05 11:11:00 this study uncovers RNF185 as the first E3 ubiquitin ligase of cyclic GMP-AMP synthase (cGAS), shedding light on the regulation of cGAS activity in innate immune responses 28273161
2014-08-09 12:13:00 these results indicate that RNF185 negatively regulates osteogenesis through the degradation of Dvl2 and down-regulation of canonical Wnt signaling pathway and suggest a possible therapeutic target in osteoporosis. 24727453
2014-01-04 13:10:00 data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation. 24019521
2012-02-04 10:31:00 Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo. 21931693

名称对应

Type IDs
Gene
UniProtKB-ID: RN185_HUMAN, A0A024R1H4_HUMAN, A0A024R1F5_HUMAN
UniprotKB: Q96GF1, A0A024R1H4, A0A024R1F5
UniParc: UPI0000036022, UPI000006DB28
EMBL: BC026040, BC012817, AK095947, CR456349, AC002073, AK291236, BC035684, CH471095, DQ296561, DQ296565, BC009504, DQ296562, AC005005, DQ296559, BC033166
Ensembl: ENSG00000138942
KO: hsa:91445
Nucleutide sequences
EMBL-CDS: BAC04659.1, BAF83925.1, EAW59949.1, AAH09504.1, AAH12817.1, AAH26040.1, EAW59947.1, AAH33166.1, AAH35684.1, ABB97509.1, ABB97508.1, ABB97506.1, CAG30235.1, ABB97512.1, EAW59950.1, EAW59951.1
Gene_ORFName: hCG_2010785, hCG_2010785
Ensembl_TRS: ENST00000266252, ENST00000326132, ENST00000518626
Protein sequencees
Ensembl_PRO: ENSP00000427755, ENSP00000266252, ENSP00000320508
RefSeq: NP_001129297.1, NP_689480.2
Others
UniRef100: UniRef100_Q96GF1, UniRef100_A0A024R1H4
UniRef90: UniRef90_Q96GF1, UniRef90_W5PIT1
UniRef50: UniRef50_W5PIT1, UniRef50_Q96GF1
UniGene: Hs.517553
CCDS: CCDS13890.1, CCDS46689.1

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