| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-28 19:06:00 | Identification of Rho GEF and RhoA Activation by Pull-Down Assays. | 32808262 |
| 2019-03-30 11:35:00 | High ARHGEF1 expression is associated with asthmatic airway hyper-responsiveness. | 29071730 |
| 2017-09-16 12:45:00 | Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac family small GTPase 1; CCL2 = C-C motif chemokine ligand 2) | 28655771 |
| 2017-06-24 11:36:00 | Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. | 28179147 |
| 2017-01-28 10:32:00 | We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of ARHGEF1, and ARHGAP36 | 26911374 |
| Type | IDs |
|---|---|
| Synonymous | GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 |
| Gene |
UniProtKB-ID:
ARHG1_HUMAN,
A0A024R0R1_HUMAN
UniprotKB:
Q92888,
A0A024R0R1
UniParc:
UPI000006D7E1,
UPI000034ECA3,
UPI0000231C94,
UPI000006D9CF
EMBL:
BC005155,
BC034013,
AC243967,
BC015652,
U64105,
BT007421,
BC067262,
Y09160,
AC010616,
BC011726,
CH471126
Ensembl:
ENSG00000076928
KO:
hsa:9138
|
| Nucleutide sequences |
EMBL-CDS:
AAH05155.2,
AAH34013.2,
AAH67262.1,
AAB17896.1,
AAP36089.1,
EAW57084.1,
AAH11726.1,
CAA70356.1,
EAW57083.1,
EAW57081.1
Gene_ORFName:
hCG_22327
Ensembl_TRS:
ENST00000378152,
ENST00000337665,
ENST00000347545,
ENST00000354532
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000346532,
ENSP00000367394,
ENSP00000344429,
ENSP00000337261
RefSeq:
NP_945328.1,
NP_004697.2,
NP_945353.1
|
| Others |
UniRef100:
UniRef100_Q92888
UniRef90:
UniRef90_Q92888
UniRef50:
UniRef50_Q92888
UniGene:
Hs.631550
CCDS:
CCDS12591.1,
CCDS12590.1,
CCDS12592.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员