| Type | Description |
|---|---|
| Definition | ceramide synthase 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-08 13:00:00 | in p53(wt) colon cancer cells chemosensitivity against oxaliplatin or 5-fluorouracil could be enhanced by downregulation of CerS5 expression leading to reduced autophagy and mitochondrial respiration. | 30059758 |
| 2017-10-07 11:10:00 | LASS5 interacts with SDHB and synergistically represses p53 and p21 activity. | 27280497 |
| 2017-09-09 11:48:00 | Studied the role of ceramide synthase 5 (LASS5 or CERS5) gene in atherosclerosis. Downregulation of LASS5 by siRNA was found to attenuate ceramide production and increase expression of some AMPK target genes in HUVEC. Found that LASS5 was involved in negative regulation of atherosclerosis-related genes, such as AMPK-alpha. | 28424433 |
| 2016-08-20 10:23:00 | These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. | 26887952 |
| 2015-08-01 10:58:00 | mRNA level of CerS5 is higher in cancerous cell lines and decreases following the induction of apoptosis. | 25779024 |
| Type | IDs |
|---|---|
| Synonymous | LASS5, Trh4 |
| Gene |
UniProtKB-ID:
CERS5_HUMAN
UniprotKB:
Q8N5B7
UniParc:
UPI0000D49511,
UPI000007101F
EMBL:
AK300937,
CH471111,
AC139016,
AC074032,
BC032565
Ensembl:
ENSG00000139624
KO:
hsa:91012
|
| Nucleutide sequences |
EMBL-CDS:
AAH32565.1,
EAW58133.1,
BAG62566.1
Ensembl_TRS:
ENST00000317551,
ENST00000422340
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000325485,
ENSP00000389050
RefSeq:
XP_024305039.1,
NP_001317999.1,
NP_671723.1,
NP_001318002.1,
NP_001268660.1,
NP_001317998.1,
XP_005269277.1,
NP_001318000.1,
NP_001318001.1,
XP_016875693.1,
XP_024305040.1
|
| Others |
UniRef100:
UniRef100_Q8N5B7
UniRef90:
UniRef90_Q8N5B7
UniRef50:
UniRef50_Q9D6K9
UniGene:
Hs.270525
CCDS:
CCDS61120.1,
CCDS8801.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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